Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer

Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management. Herein, we demonstrate how targeting SOAT1 promotes YAP ex...

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Detalles Bibliográficos
Autores principales: Xu, Huanji, Xia, Hongwei, Zhou, Sheng, Tang, Qiulin, Bi, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910478/
https://www.ncbi.nlm.nih.gov/pubmed/33637695
http://dx.doi.org/10.1038/s41420-021-00421-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910478/
https://www.ncbi.nlm.nih.gov/pubmed/33637695
http://dx.doi.org/10.1038/s41420-021-00421-3

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