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Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer

Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management. Herein, we demonstrate how targeting SOAT1 promotes YAP ex...

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Detalles Bibliográficos
Autores principales:	Xu, Huanji, Xia, Hongwei, Zhou, Sheng, Tang, Qiulin, Bi, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910478/ https://www.ncbi.nlm.nih.gov/pubmed/33637695 http://dx.doi.org/10.1038/s41420-021-00421-3

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