Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. To define the mechanistic basis of clonal hematopoiesis...

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Detalles Bibliográficos
Autores principales: Kennedy, Alyssa L., Myers, Kasiani C., Bowman, James, Gibson, Christopher J., Camarda, Nicholas D., Furutani, Elissa, Muscato, Gwen M., Klein, Robert H., Ballotti, Kaitlyn, Liu, Shanshan, Harris, Chad E., Galvin, Ashley, Malsch, Maggie, Dale, David, Gansner, John M., Nakano, Taizo A., Bertuch, Alison, Vlachos, Adrianna, Lipton, Jeffrey M., Castillo, Paul, Connelly, James, Churpek, Jane, Edwards, John R., Hijiya, Nobuko, Ho, Richard H., Hofmann, Inga, Huang, James N., Keel, Siobán, Lamble, Adam, Lau, Bonnie W., Norkin, Maxim, Stieglitz, Elliot, Stock, Wendy, Walkovich, Kelly, Boettcher, Steffen, Brendel, Christian, Fleming, Mark D., Davies, Stella M., Weller, Edie A., Bahl, Christopher, Carter, Scott L., Shimamura, Akiko, Lindsley, R. Coleman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910481/
https://www.ncbi.nlm.nih.gov/pubmed/33637765
http://dx.doi.org/10.1038/s41467-021-21588-4

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