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Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease

Despite recent discoveries in genome-wide association studies (GWAS) of genomic variants associated with Alzheimer’s disease (AD), its underlying biological mechanisms are still elusive. The discovery of novel AD-associated genetic variants, particularly in coding regions and from APOE ε4 non-carrie...

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Detalles Bibliográficos
Autores principales: He, Liang, Loika, Yury, Park, Yongjin, Bennett, David A., Kellis, Manolis, Kulminski, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910483/
https://www.ncbi.nlm.nih.gov/pubmed/33637690
http://dx.doi.org/10.1038/s41398-021-01263-4