Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series

• TP53 variant negative high-grade serous ovarian cancer is rare and can still show p53 abnormal immunohistochemistry. • Diagnostic and therapeutic considerations include pathologic, molecular and clinical domains. • Genetic reassessment through more comprehensive assays should be considered to ensu...

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Detalles Bibliográficos
Autores principales: Kasherman, Lawrence, Garg, Swati, Tchrakian, Nairi, Clarke, Blaise, Karakasis, Katherine, Kim, Raymond H., Stockley, Tracy L., Dhani, Neesha, Oza, Amit M., Lheureux, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910505/
https://www.ncbi.nlm.nih.gov/pubmed/33718561
http://dx.doi.org/10.1016/j.gore.2021.100729
Descripción
Sumario:• TP53 variant negative high-grade serous ovarian cancer is rare and can still show p53 abnormal immunohistochemistry. • Diagnostic and therapeutic considerations include pathologic, molecular and clinical domains. • Genetic reassessment through more comprehensive assays should be considered to ensure no missed rare or complex variants. • Presence of BRCA mutations can occur in TP53 variant high-grade serous ovarian cancer.

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