Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series

• TP53 variant negative high-grade serous ovarian cancer is rare and can still show p53 abnormal immunohistochemistry. • Diagnostic and therapeutic considerations include pathologic, molecular and clinical domains. • Genetic reassessment through more comprehensive assays should be considered to ensu...

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Autores principales: Kasherman, Lawrence, Garg, Swati, Tchrakian, Nairi, Clarke, Blaise, Karakasis, Katherine, Kim, Raymond H., Stockley, Tracy L., Dhani, Neesha, Oza, Amit M., Lheureux, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910505/
https://www.ncbi.nlm.nih.gov/pubmed/33718561
http://dx.doi.org/10.1016/j.gore.2021.100729
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author Kasherman, Lawrence
Garg, Swati
Tchrakian, Nairi
Clarke, Blaise
Karakasis, Katherine
Kim, Raymond H.
Stockley, Tracy L.
Dhani, Neesha
Oza, Amit M.
Lheureux, Stephanie
author_facet Kasherman, Lawrence
Garg, Swati
Tchrakian, Nairi
Clarke, Blaise
Karakasis, Katherine
Kim, Raymond H.
Stockley, Tracy L.
Dhani, Neesha
Oza, Amit M.
Lheureux, Stephanie
author_sort Kasherman, Lawrence
collection PubMed
description • TP53 variant negative high-grade serous ovarian cancer is rare and can still show p53 abnormal immunohistochemistry. • Diagnostic and therapeutic considerations include pathologic, molecular and clinical domains. • Genetic reassessment through more comprehensive assays should be considered to ensure no missed rare or complex variants. • Presence of BRCA mutations can occur in TP53 variant high-grade serous ovarian cancer.
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spelling pubmed-79105052021-03-12 Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series Kasherman, Lawrence Garg, Swati Tchrakian, Nairi Clarke, Blaise Karakasis, Katherine Kim, Raymond H. Stockley, Tracy L. Dhani, Neesha Oza, Amit M. Lheureux, Stephanie Gynecol Oncol Rep Case Report • TP53 variant negative high-grade serous ovarian cancer is rare and can still show p53 abnormal immunohistochemistry. • Diagnostic and therapeutic considerations include pathologic, molecular and clinical domains. • Genetic reassessment through more comprehensive assays should be considered to ensure no missed rare or complex variants. • Presence of BRCA mutations can occur in TP53 variant high-grade serous ovarian cancer. Elsevier 2021-02-12 /pmc/articles/PMC7910505/ /pubmed/33718561 http://dx.doi.org/10.1016/j.gore.2021.100729 Text en © 2021 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kasherman, Lawrence
Garg, Swati
Tchrakian, Nairi
Clarke, Blaise
Karakasis, Katherine
Kim, Raymond H.
Stockley, Tracy L.
Dhani, Neesha
Oza, Amit M.
Lheureux, Stephanie
Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series
title Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series
title_full Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series
title_fullStr Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series
title_full_unstemmed Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series
title_short Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series
title_sort can tp53 variant negative be high-grade serous ovarian carcinoma? a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910505/
https://www.ncbi.nlm.nih.gov/pubmed/33718561
http://dx.doi.org/10.1016/j.gore.2021.100729
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