Cargando…

Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses

Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic. Here, we assess the immunogenicity and efficacy of a highly pathogenic avian influenza (H...

Descripción completa

Detalles Bibliográficos
Autores principales: Radvak, Peter, Kosikova, Martina, Kuo, Yuan-Chia, Li, Xing, Garner, Richard, Schmeisser, Falko, Kosik, Ivan, Ye, Zhiping, Weir, Jerry P., Yewdell, Jonathan W., Xie, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910538/
https://www.ncbi.nlm.nih.gov/pubmed/33637737
http://dx.doi.org/10.1038/s41541-021-00295-7
_version_ 1783656139420860416
author Radvak, Peter
Kosikova, Martina
Kuo, Yuan-Chia
Li, Xing
Garner, Richard
Schmeisser, Falko
Kosik, Ivan
Ye, Zhiping
Weir, Jerry P.
Yewdell, Jonathan W.
Xie, Hang
author_facet Radvak, Peter
Kosikova, Martina
Kuo, Yuan-Chia
Li, Xing
Garner, Richard
Schmeisser, Falko
Kosik, Ivan
Ye, Zhiping
Weir, Jerry P.
Yewdell, Jonathan W.
Xie, Hang
author_sort Radvak, Peter
collection PubMed
description Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic. Here, we assess the immunogenicity and efficacy of a highly pathogenic avian influenza (HPAI) A/Guangdong/17SF003/2016 (GD/16)-extracted hemagglutinin (eHA) vaccine. GD/16 eHA induces robust H7-specific antibody responses in mice with a marked adjuvant antigen-sparing effect. Mice immunized with adjuvanted GD/16 eHA are protected from the lethal LPAI and HPAI H7N9 challenges, in stark contrast to low antibody titers and high mortality in mice receiving adjuvanted LPAI H7 eHAs. The protection correlates well with the magnitude of the H7-specific antibody response (IgG and microneutralization) or HA group 2 stem-specific IgG. Inclusion of adjuvanted GD/16 eHA in heterologous prime-boost improves the immunogenicity and protection of LPAI H7 HAs in mice. Our findings support the inclusion of GD/16-derived CVV in the pandemic preparedness vaccine stockpile.
format Online
Article
Text
id pubmed-7910538
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-79105382021-03-04 Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses Radvak, Peter Kosikova, Martina Kuo, Yuan-Chia Li, Xing Garner, Richard Schmeisser, Falko Kosik, Ivan Ye, Zhiping Weir, Jerry P. Yewdell, Jonathan W. Xie, Hang NPJ Vaccines Article Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic. Here, we assess the immunogenicity and efficacy of a highly pathogenic avian influenza (HPAI) A/Guangdong/17SF003/2016 (GD/16)-extracted hemagglutinin (eHA) vaccine. GD/16 eHA induces robust H7-specific antibody responses in mice with a marked adjuvant antigen-sparing effect. Mice immunized with adjuvanted GD/16 eHA are protected from the lethal LPAI and HPAI H7N9 challenges, in stark contrast to low antibody titers and high mortality in mice receiving adjuvanted LPAI H7 eHAs. The protection correlates well with the magnitude of the H7-specific antibody response (IgG and microneutralization) or HA group 2 stem-specific IgG. Inclusion of adjuvanted GD/16 eHA in heterologous prime-boost improves the immunogenicity and protection of LPAI H7 HAs in mice. Our findings support the inclusion of GD/16-derived CVV in the pandemic preparedness vaccine stockpile. Nature Publishing Group UK 2021-02-26 /pmc/articles/PMC7910538/ /pubmed/33637737 http://dx.doi.org/10.1038/s41541-021-00295-7 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Radvak, Peter
Kosikova, Martina
Kuo, Yuan-Chia
Li, Xing
Garner, Richard
Schmeisser, Falko
Kosik, Ivan
Ye, Zhiping
Weir, Jerry P.
Yewdell, Jonathan W.
Xie, Hang
Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses
title Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses
title_full Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses
title_fullStr Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses
title_full_unstemmed Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses
title_short Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses
title_sort highly pathogenic avian influenza a/guangdong/17sf003/2016 is immunogenic and induces cross-protection against antigenically divergent h7n9 viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910538/
https://www.ncbi.nlm.nih.gov/pubmed/33637737
http://dx.doi.org/10.1038/s41541-021-00295-7
work_keys_str_mv AT radvakpeter highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT kosikovamartina highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT kuoyuanchia highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT lixing highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT garnerrichard highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT schmeisserfalko highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT kosikivan highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT yezhiping highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT weirjerryp highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT yewdelljonathanw highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses
AT xiehang highlypathogenicavianinfluenzaaguangdong17sf0032016isimmunogenicandinducescrossprotectionagainstantigenicallydivergenth7n9viruses