A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

Bulky DNA lesions in transcribed strands block RNA polymerase II (RNAPII) elongation and induce a genome-wide transcriptional arrest. The transcription-coupled repair (TCR) pathway efficiently removes transcription-blocking DNA lesions, but how transcription is restored in the genome following DNA r...

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Detalles Bibliográficos
Autores principales: van den Heuvel, Diana, Spruijt, Cornelia G., González-Prieto, Román, Kragten, Angela, Paulsen, Michelle T., Zhou, Di, Wu, Haoyu, Apelt, Katja, van der Weegen, Yana, Yang, Kevin, Dijk, Madelon, Daxinger, Lucia, Marteijn, Jurgen A., Vertegaal, Alfred C. O., Ljungman, Mats, Vermeulen, Michiel, Luijsterburg, Martijn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910549/
https://www.ncbi.nlm.nih.gov/pubmed/33637760
http://dx.doi.org/10.1038/s41467-021-21520-w

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