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High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

Mitochondrial dysfunction and impaired Ca(2+) handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of phosphorylation, and the Orai1 (Ca(2+) release-activated calcium channel protein 1) calc...

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Detalles Bibliográficos
Autores principales:	Wu, Qing-Rui, Zheng, Dan-Lin, Liu, Pei-Ming, Yang, Hui, Li, Lu-An, Kuang, Su-Juan, Lai, Ying-Yu, Rao, Fang, Xue, Yu-Mei, Lin, Ji-Jin, Liu, Shuang-Xin, Chen, Chun-Bo, Deng, Chun-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910592/ https://www.ncbi.nlm.nih.gov/pubmed/33637715 http://dx.doi.org/10.1038/s41419-021-03502-4

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