Cargando…
AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo
Axonal damage is an early step in traumatic and neurodegenerative disorders of the central nervous system (CNS). Damaged axons are not able to regenerate sufficiently in the adult mammalian CNS, leading to permanent neurological deficits. Recently, we showed that inhibition of the autophagic protein...
Autores principales: | Ribas, Vinicius Toledo, Vahsen, Björn Friedhelm, Tatenhorst, Lars, Estrada, Veronica, Dambeck, Vivian, Almeida, Raquel Alves, Bähr, Mathias, Michel, Uwe, Koch, Jan Christoph, Müller, Hans Werner, Lingor, Paul |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910615/ https://www.ncbi.nlm.nih.gov/pubmed/33637688 http://dx.doi.org/10.1038/s41419-021-03503-3 |
Ejemplares similares
-
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing
por: Vahsen, Björn Friedhelm, et al.
Publicado: (2020) -
Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease
por: Tönges, Lars, et al.
Publicado: (2014) -
ULK1 as a novel therapeutic target in neurodegeneration
por: Vahsen, Björn Friedhelm, et al.
Publicado: (2020) -
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation
por: Carboni, Eleonora, et al.
Publicado: (2017) -
Calcium channel inhibition-mediated axonal stabilization improves axonal regeneration after optic nerve crush
por: Ribas, Vinicius T., et al.
Publicado: (2016)