Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response

PURPOSE: Heme depletion, through inhibition of ferrochelatase (FECH), blocks retinal and choroidal neovascularization. Both pharmacologic FECH inhibition and a partial loss-of-function Fech mutation (Fech(m1Pas)) are associated with decreased neovascularization. However, the ocular physiology of Fec...

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Detalles Bibliográficos
Autores principales: Sardar Pasha, S. P. B., Shetty, Trupti, Lambert-Cheatham, Nathan A., Sishtla, Kamakshi, Mathew, Deepa, Muniyandi, Anbukkarasi, Patwari, Neeta, Bhatwadekar, Ashay D., Corson, Timothy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910629/
https://www.ncbi.nlm.nih.gov/pubmed/33620374
http://dx.doi.org/10.1167/iovs.62.2.36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910629/
https://www.ncbi.nlm.nih.gov/pubmed/33620374
http://dx.doi.org/10.1167/iovs.62.2.36

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