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Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan
Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was c...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910831/ https://www.ncbi.nlm.nih.gov/pubmed/33573054 http://dx.doi.org/10.3390/v13020207 |
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author | Honda, Masayuki Asakura, Hiroyuki Kanda, Tatsuo Somura, Yoshiko Ishii, Tomotaka Yamana, Yoichiro Kaneko, Tomohiro Mizutani, Taku Takahashi, Hiroshi Kumagawa, Mariko Sasaki, Reina Masuzaki, Ryota Kanezawa, Shini Nirei, Kazushige Yamagami, Hiroaki Matsumoto, Naoki Nagashima, Mami Chiba, Takashi Moriyama, Mitsuhiko |
author_facet | Honda, Masayuki Asakura, Hiroyuki Kanda, Tatsuo Somura, Yoshiko Ishii, Tomotaka Yamana, Yoichiro Kaneko, Tomohiro Mizutani, Taku Takahashi, Hiroshi Kumagawa, Mariko Sasaki, Reina Masuzaki, Ryota Kanezawa, Shini Nirei, Kazushige Yamagami, Hiroaki Matsumoto, Naoki Nagashima, Mami Chiba, Takashi Moriyama, Mitsuhiko |
author_sort | Honda, Masayuki |
collection | PubMed |
description | Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection. |
format | Online Article Text |
id | pubmed-7910831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79108312021-02-28 Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan Honda, Masayuki Asakura, Hiroyuki Kanda, Tatsuo Somura, Yoshiko Ishii, Tomotaka Yamana, Yoichiro Kaneko, Tomohiro Mizutani, Taku Takahashi, Hiroshi Kumagawa, Mariko Sasaki, Reina Masuzaki, Ryota Kanezawa, Shini Nirei, Kazushige Yamagami, Hiroaki Matsumoto, Naoki Nagashima, Mami Chiba, Takashi Moriyama, Mitsuhiko Viruses Article Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection. MDPI 2021-01-29 /pmc/articles/PMC7910831/ /pubmed/33573054 http://dx.doi.org/10.3390/v13020207 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Honda, Masayuki Asakura, Hiroyuki Kanda, Tatsuo Somura, Yoshiko Ishii, Tomotaka Yamana, Yoichiro Kaneko, Tomohiro Mizutani, Taku Takahashi, Hiroshi Kumagawa, Mariko Sasaki, Reina Masuzaki, Ryota Kanezawa, Shini Nirei, Kazushige Yamagami, Hiroaki Matsumoto, Naoki Nagashima, Mami Chiba, Takashi Moriyama, Mitsuhiko Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan |
title | Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan |
title_full | Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan |
title_fullStr | Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan |
title_full_unstemmed | Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan |
title_short | Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan |
title_sort | male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910831/ https://www.ncbi.nlm.nih.gov/pubmed/33573054 http://dx.doi.org/10.3390/v13020207 |
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