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Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan

Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was c...

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Autores principales: Honda, Masayuki, Asakura, Hiroyuki, Kanda, Tatsuo, Somura, Yoshiko, Ishii, Tomotaka, Yamana, Yoichiro, Kaneko, Tomohiro, Mizutani, Taku, Takahashi, Hiroshi, Kumagawa, Mariko, Sasaki, Reina, Masuzaki, Ryota, Kanezawa, Shini, Nirei, Kazushige, Yamagami, Hiroaki, Matsumoto, Naoki, Nagashima, Mami, Chiba, Takashi, Moriyama, Mitsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910831/
https://www.ncbi.nlm.nih.gov/pubmed/33573054
http://dx.doi.org/10.3390/v13020207
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author Honda, Masayuki
Asakura, Hiroyuki
Kanda, Tatsuo
Somura, Yoshiko
Ishii, Tomotaka
Yamana, Yoichiro
Kaneko, Tomohiro
Mizutani, Taku
Takahashi, Hiroshi
Kumagawa, Mariko
Sasaki, Reina
Masuzaki, Ryota
Kanezawa, Shini
Nirei, Kazushige
Yamagami, Hiroaki
Matsumoto, Naoki
Nagashima, Mami
Chiba, Takashi
Moriyama, Mitsuhiko
author_facet Honda, Masayuki
Asakura, Hiroyuki
Kanda, Tatsuo
Somura, Yoshiko
Ishii, Tomotaka
Yamana, Yoichiro
Kaneko, Tomohiro
Mizutani, Taku
Takahashi, Hiroshi
Kumagawa, Mariko
Sasaki, Reina
Masuzaki, Ryota
Kanezawa, Shini
Nirei, Kazushige
Yamagami, Hiroaki
Matsumoto, Naoki
Nagashima, Mami
Chiba, Takashi
Moriyama, Mitsuhiko
author_sort Honda, Masayuki
collection PubMed
description Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection.
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spelling pubmed-79108312021-02-28 Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan Honda, Masayuki Asakura, Hiroyuki Kanda, Tatsuo Somura, Yoshiko Ishii, Tomotaka Yamana, Yoichiro Kaneko, Tomohiro Mizutani, Taku Takahashi, Hiroshi Kumagawa, Mariko Sasaki, Reina Masuzaki, Ryota Kanezawa, Shini Nirei, Kazushige Yamagami, Hiroaki Matsumoto, Naoki Nagashima, Mami Chiba, Takashi Moriyama, Mitsuhiko Viruses Article Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection. MDPI 2021-01-29 /pmc/articles/PMC7910831/ /pubmed/33573054 http://dx.doi.org/10.3390/v13020207 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Honda, Masayuki
Asakura, Hiroyuki
Kanda, Tatsuo
Somura, Yoshiko
Ishii, Tomotaka
Yamana, Yoichiro
Kaneko, Tomohiro
Mizutani, Taku
Takahashi, Hiroshi
Kumagawa, Mariko
Sasaki, Reina
Masuzaki, Ryota
Kanezawa, Shini
Nirei, Kazushige
Yamagami, Hiroaki
Matsumoto, Naoki
Nagashima, Mami
Chiba, Takashi
Moriyama, Mitsuhiko
Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan
title Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan
title_full Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan
title_fullStr Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan
title_full_unstemmed Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan
title_short Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan
title_sort male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910831/
https://www.ncbi.nlm.nih.gov/pubmed/33573054
http://dx.doi.org/10.3390/v13020207
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