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Association of Colonic Diverticula with Colorectal Adenomas and Cancer

Background and Objectives: Conflicting evidence is reported regarding any association between colonic diverticula with colorectal adenomas or cancer. The present study aimed to evaluate, in a cohort of Caucasian patients, the association between colonic diverticula and colorectal polyps and cancer....

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Autores principales: Viscido, Angelo, Ciccone, Fabiana, Vernia, Filippo, Gabrieli, Dolores, Capannolo, Annalisa, Stefanelli, Gianpiero, Necozione, Stefano, Valerii, Giorgio, Ashktorab, Hassan, Latella, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910864/
https://www.ncbi.nlm.nih.gov/pubmed/33504050
http://dx.doi.org/10.3390/medicina57020108
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author Viscido, Angelo
Ciccone, Fabiana
Vernia, Filippo
Gabrieli, Dolores
Capannolo, Annalisa
Stefanelli, Gianpiero
Necozione, Stefano
Valerii, Giorgio
Ashktorab, Hassan
Latella, Giovanni
author_facet Viscido, Angelo
Ciccone, Fabiana
Vernia, Filippo
Gabrieli, Dolores
Capannolo, Annalisa
Stefanelli, Gianpiero
Necozione, Stefano
Valerii, Giorgio
Ashktorab, Hassan
Latella, Giovanni
author_sort Viscido, Angelo
collection PubMed
description Background and Objectives: Conflicting evidence is reported regarding any association between colonic diverticula with colorectal adenomas or cancer. The present study aimed to evaluate, in a cohort of Caucasian patients, the association between colonic diverticula and colorectal polyps and cancer. Materials and Methods: All consecutive patients undergoing colonoscopy at our institution were included in the study. The presence and location of diverticula, polyps, and cancers were recorded. Histologically, polyps were classified as adenoma (with low or high dysplasia), hyperplastic, or inflammatory. The relative risk of the association of polyps and cancer with diverticula was assessed. Multiple logistic regression analyses, including age, sex, family history for colorectal cancer (CRC), and family history for diverticula, were carried out. Results: During the study period, 1490 patients were enrolled; 37.2% (n = 555) showed colonic diverticula or polyps or CRC (308 males, mean age 66 years). Particularly, 12.3% (n = 183) patients presented only diverticula, 13.7% (n = 204) only polyps or cancer, 11.3% (n = 168) both diseases, and 62.7% (n = 935) neither diverticula nor polyps and cancer. A total of 38 patients presented colorectal cancer, 17 of which had also diverticula. A significant increase in relative risk (RR 2.81, 95% CI 2.27–3.47, p < 0.0001) of colorectal adenoma and cancer in patients with colonic diverticula was found. At multivariate analysis, only diverticula resulted to be significantly associated with colorectal adenomas and cancer (Odds Ratio, OR 3.86, 95% CI 2.90–5.14, p < 0.0001). Conclusions: A significant association of colonic diverticula with colorectal adenoma or cancer was found. This implies that patients with colonic diverticula require a vigilant follow-up procedure for the prevention of colorectal cancer from those applicable to the general population.
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spelling pubmed-79108642021-02-28 Association of Colonic Diverticula with Colorectal Adenomas and Cancer Viscido, Angelo Ciccone, Fabiana Vernia, Filippo Gabrieli, Dolores Capannolo, Annalisa Stefanelli, Gianpiero Necozione, Stefano Valerii, Giorgio Ashktorab, Hassan Latella, Giovanni Medicina (Kaunas) Article Background and Objectives: Conflicting evidence is reported regarding any association between colonic diverticula with colorectal adenomas or cancer. The present study aimed to evaluate, in a cohort of Caucasian patients, the association between colonic diverticula and colorectal polyps and cancer. Materials and Methods: All consecutive patients undergoing colonoscopy at our institution were included in the study. The presence and location of diverticula, polyps, and cancers were recorded. Histologically, polyps were classified as adenoma (with low or high dysplasia), hyperplastic, or inflammatory. The relative risk of the association of polyps and cancer with diverticula was assessed. Multiple logistic regression analyses, including age, sex, family history for colorectal cancer (CRC), and family history for diverticula, were carried out. Results: During the study period, 1490 patients were enrolled; 37.2% (n = 555) showed colonic diverticula or polyps or CRC (308 males, mean age 66 years). Particularly, 12.3% (n = 183) patients presented only diverticula, 13.7% (n = 204) only polyps or cancer, 11.3% (n = 168) both diseases, and 62.7% (n = 935) neither diverticula nor polyps and cancer. A total of 38 patients presented colorectal cancer, 17 of which had also diverticula. A significant increase in relative risk (RR 2.81, 95% CI 2.27–3.47, p < 0.0001) of colorectal adenoma and cancer in patients with colonic diverticula was found. At multivariate analysis, only diverticula resulted to be significantly associated with colorectal adenomas and cancer (Odds Ratio, OR 3.86, 95% CI 2.90–5.14, p < 0.0001). Conclusions: A significant association of colonic diverticula with colorectal adenoma or cancer was found. This implies that patients with colonic diverticula require a vigilant follow-up procedure for the prevention of colorectal cancer from those applicable to the general population. MDPI 2021-01-25 /pmc/articles/PMC7910864/ /pubmed/33504050 http://dx.doi.org/10.3390/medicina57020108 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Viscido, Angelo
Ciccone, Fabiana
Vernia, Filippo
Gabrieli, Dolores
Capannolo, Annalisa
Stefanelli, Gianpiero
Necozione, Stefano
Valerii, Giorgio
Ashktorab, Hassan
Latella, Giovanni
Association of Colonic Diverticula with Colorectal Adenomas and Cancer
title Association of Colonic Diverticula with Colorectal Adenomas and Cancer
title_full Association of Colonic Diverticula with Colorectal Adenomas and Cancer
title_fullStr Association of Colonic Diverticula with Colorectal Adenomas and Cancer
title_full_unstemmed Association of Colonic Diverticula with Colorectal Adenomas and Cancer
title_short Association of Colonic Diverticula with Colorectal Adenomas and Cancer
title_sort association of colonic diverticula with colorectal adenomas and cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910864/
https://www.ncbi.nlm.nih.gov/pubmed/33504050
http://dx.doi.org/10.3390/medicina57020108
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