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Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?

Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in the regulation of food intake and body weight, has been implicated in the development and maintenance of Anorexia nervosa (AN). The majority of previous studies reported lower BDNF levels in acutely underweight AN patients (acAN) a...

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Autores principales: Steinhäuser, Jonas L., King, Joseph A., Tam, Friederike I., Seidel, Maria, Biemann, Ronald, Wronski, Marie-Louis, Geisler, Daniel, Roessner, Veit, Ehrlich, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910942/
https://www.ncbi.nlm.nih.gov/pubmed/33572701
http://dx.doi.org/10.3390/nu13020432
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author Steinhäuser, Jonas L.
King, Joseph A.
Tam, Friederike I.
Seidel, Maria
Biemann, Ronald
Wronski, Marie-Louis
Geisler, Daniel
Roessner, Veit
Ehrlich, Stefan
author_facet Steinhäuser, Jonas L.
King, Joseph A.
Tam, Friederike I.
Seidel, Maria
Biemann, Ronald
Wronski, Marie-Louis
Geisler, Daniel
Roessner, Veit
Ehrlich, Stefan
author_sort Steinhäuser, Jonas L.
collection PubMed
description Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in the regulation of food intake and body weight, has been implicated in the development and maintenance of Anorexia nervosa (AN). The majority of previous studies reported lower BDNF levels in acutely underweight AN patients (acAN) and increasing levels after weight rehabilitation. Here, we investigated serum BDNF concentrations in the largest known AN sample to date, both before and after weight restoration therapy. Serum BDNF was measured in 259 female volunteers: 77 in-patient acAN participants of the restrictive type (47 reassessed after short-term weight rehabilitation), 62 individuals long-term recovered from AN, and 120 healthy controls. We validated our findings in a post-hoc mega-analysis in which we reanalyzed combined data from the current sample and those from our previous study on BDNF in AN (combined sample: 389 participants). All analyses carefully accounted for known determinants of BDNF (age, sex, storage time of blood samples). We further assessed relationships with relevant clinical variables (body-mass-index, physical activity, symptoms). Contrary to our hypotheses, we found zero significant differences in either cross-sectional or longitudinal comparisons and no significant relationships with clinical variables. Together, our study suggests that BDNF may not be a reliable state- or trait-marker in AN after all.
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spelling pubmed-79109422021-02-28 Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa? Steinhäuser, Jonas L. King, Joseph A. Tam, Friederike I. Seidel, Maria Biemann, Ronald Wronski, Marie-Louis Geisler, Daniel Roessner, Veit Ehrlich, Stefan Nutrients Article Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in the regulation of food intake and body weight, has been implicated in the development and maintenance of Anorexia nervosa (AN). The majority of previous studies reported lower BDNF levels in acutely underweight AN patients (acAN) and increasing levels after weight rehabilitation. Here, we investigated serum BDNF concentrations in the largest known AN sample to date, both before and after weight restoration therapy. Serum BDNF was measured in 259 female volunteers: 77 in-patient acAN participants of the restrictive type (47 reassessed after short-term weight rehabilitation), 62 individuals long-term recovered from AN, and 120 healthy controls. We validated our findings in a post-hoc mega-analysis in which we reanalyzed combined data from the current sample and those from our previous study on BDNF in AN (combined sample: 389 participants). All analyses carefully accounted for known determinants of BDNF (age, sex, storage time of blood samples). We further assessed relationships with relevant clinical variables (body-mass-index, physical activity, symptoms). Contrary to our hypotheses, we found zero significant differences in either cross-sectional or longitudinal comparisons and no significant relationships with clinical variables. Together, our study suggests that BDNF may not be a reliable state- or trait-marker in AN after all. MDPI 2021-01-29 /pmc/articles/PMC7910942/ /pubmed/33572701 http://dx.doi.org/10.3390/nu13020432 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Steinhäuser, Jonas L.
King, Joseph A.
Tam, Friederike I.
Seidel, Maria
Biemann, Ronald
Wronski, Marie-Louis
Geisler, Daniel
Roessner, Veit
Ehrlich, Stefan
Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?
title Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?
title_full Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?
title_fullStr Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?
title_full_unstemmed Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?
title_short Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?
title_sort is serum bdnf altered in acute, short- and long-term recovered restrictive type anorexia nervosa?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910942/
https://www.ncbi.nlm.nih.gov/pubmed/33572701
http://dx.doi.org/10.3390/nu13020432
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