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The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics

The main role of vitamin D is calcium homeostasis and bone metabolism, although its activity as an immuno-modulator and its anti-inflammatory effect is well-known. Low blood vitamin D levels are common among patients with inflammatory bowel disease (IBD). Whether low vitamin D levels could affect th...

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Autores principales: Valvano, Marco, Magistroni, Marco, Mancusi, Antonio, D’Ascenzo, Debora, Longo, Salvatore, Stefanelli, Gianpiero, Vernia, Filippo, Viscido, Angelo, Necozione, Stefano, Latella, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910959/
https://www.ncbi.nlm.nih.gov/pubmed/33499406
http://dx.doi.org/10.3390/nu13020323
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author Valvano, Marco
Magistroni, Marco
Mancusi, Antonio
D’Ascenzo, Debora
Longo, Salvatore
Stefanelli, Gianpiero
Vernia, Filippo
Viscido, Angelo
Necozione, Stefano
Latella, Giovanni
author_facet Valvano, Marco
Magistroni, Marco
Mancusi, Antonio
D’Ascenzo, Debora
Longo, Salvatore
Stefanelli, Gianpiero
Vernia, Filippo
Viscido, Angelo
Necozione, Stefano
Latella, Giovanni
author_sort Valvano, Marco
collection PubMed
description The main role of vitamin D is calcium homeostasis and bone metabolism, although its activity as an immuno-modulator and its anti-inflammatory effect is well-known. Low blood vitamin D levels are common among patients with inflammatory bowel disease (IBD). Whether low vitamin D levels could affect the disease activity or it is an effect of a worse condition of the disease is still unclear. This study aimed to investigate the role of blood vitamin D levels to identify the clinical, endoscopic, and histological activity in a cohort of patients with ulcerative colitis (UC) or Crohn’s disease (CD) on therapy with biological drugs. In this retrospective cohort study, 50 IBD patients (24 UC and 26 CD) that underwent colonoscopy from January 2017 to January 2020 with a concomitant serological evaluation of vitamin D were included. Patients with clinical, endoscopic, and histological activity and those who lost their clinical response to the biological drug had lower vitamin D levels compared to patients in remission or patients that did not change therapeutic regimens. A receiver operating characteristic (ROC) analysis and Youden’s Index were performed to assess the optimal vitamin D levels to identify patients with the active disease. The ROC analysis showed an area under the curve (AUC) of 0.709 (p = 0.005; confidence interval (CI): 0.564–0.829), 0.769 (p < 0.001; CI: 0.628–0.876), and 0.810 (p < 0.001; CI: 0.670–0.910) for the clinical, endoscopic, and histological outcomes, respectively. The optimal vitamin D cut-off was ≤25 ng/mL. The vitamin D level is an additional useful tool in the evaluation of IBD patients with good accuracy to predict their endoscopic and histological activity and clinical response to biologics.
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spelling pubmed-79109592021-02-28 The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics Valvano, Marco Magistroni, Marco Mancusi, Antonio D’Ascenzo, Debora Longo, Salvatore Stefanelli, Gianpiero Vernia, Filippo Viscido, Angelo Necozione, Stefano Latella, Giovanni Nutrients Article The main role of vitamin D is calcium homeostasis and bone metabolism, although its activity as an immuno-modulator and its anti-inflammatory effect is well-known. Low blood vitamin D levels are common among patients with inflammatory bowel disease (IBD). Whether low vitamin D levels could affect the disease activity or it is an effect of a worse condition of the disease is still unclear. This study aimed to investigate the role of blood vitamin D levels to identify the clinical, endoscopic, and histological activity in a cohort of patients with ulcerative colitis (UC) or Crohn’s disease (CD) on therapy with biological drugs. In this retrospective cohort study, 50 IBD patients (24 UC and 26 CD) that underwent colonoscopy from January 2017 to January 2020 with a concomitant serological evaluation of vitamin D were included. Patients with clinical, endoscopic, and histological activity and those who lost their clinical response to the biological drug had lower vitamin D levels compared to patients in remission or patients that did not change therapeutic regimens. A receiver operating characteristic (ROC) analysis and Youden’s Index were performed to assess the optimal vitamin D levels to identify patients with the active disease. The ROC analysis showed an area under the curve (AUC) of 0.709 (p = 0.005; confidence interval (CI): 0.564–0.829), 0.769 (p < 0.001; CI: 0.628–0.876), and 0.810 (p < 0.001; CI: 0.670–0.910) for the clinical, endoscopic, and histological outcomes, respectively. The optimal vitamin D cut-off was ≤25 ng/mL. The vitamin D level is an additional useful tool in the evaluation of IBD patients with good accuracy to predict their endoscopic and histological activity and clinical response to biologics. MDPI 2021-01-22 /pmc/articles/PMC7910959/ /pubmed/33499406 http://dx.doi.org/10.3390/nu13020323 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valvano, Marco
Magistroni, Marco
Mancusi, Antonio
D’Ascenzo, Debora
Longo, Salvatore
Stefanelli, Gianpiero
Vernia, Filippo
Viscido, Angelo
Necozione, Stefano
Latella, Giovanni
The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics
title The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics
title_full The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics
title_fullStr The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics
title_full_unstemmed The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics
title_short The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics
title_sort usefulness of serum vitamin d levels in the assessment of ibd activity and response to biologics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910959/
https://www.ncbi.nlm.nih.gov/pubmed/33499406
http://dx.doi.org/10.3390/nu13020323
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