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Creatine in Health and Disease
Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910963/ https://www.ncbi.nlm.nih.gov/pubmed/33572884 http://dx.doi.org/10.3390/nu13020447 |
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author | Kreider, Richard B. Stout, Jeffery R. |
author_facet | Kreider, Richard B. Stout, Jeffery R. |
author_sort | Kreider, Richard B. |
collection | PubMed |
description | Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine’s role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan. |
format | Online Article Text |
id | pubmed-7910963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79109632021-02-28 Creatine in Health and Disease Kreider, Richard B. Stout, Jeffery R. Nutrients Review Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine’s role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan. MDPI 2021-01-29 /pmc/articles/PMC7910963/ /pubmed/33572884 http://dx.doi.org/10.3390/nu13020447 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kreider, Richard B. Stout, Jeffery R. Creatine in Health and Disease |
title | Creatine in Health and Disease |
title_full | Creatine in Health and Disease |
title_fullStr | Creatine in Health and Disease |
title_full_unstemmed | Creatine in Health and Disease |
title_short | Creatine in Health and Disease |
title_sort | creatine in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910963/ https://www.ncbi.nlm.nih.gov/pubmed/33572884 http://dx.doi.org/10.3390/nu13020447 |
work_keys_str_mv | AT kreiderrichardb creatineinhealthanddisease AT stoutjefferyr creatineinhealthanddisease |