Cargando…

Creatine in Health and Disease

Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kreider, Richard B., Stout, Jeffery R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910963/
https://www.ncbi.nlm.nih.gov/pubmed/33572884
http://dx.doi.org/10.3390/nu13020447
_version_ 1783656235226103808
author Kreider, Richard B.
Stout, Jeffery R.
author_facet Kreider, Richard B.
Stout, Jeffery R.
author_sort Kreider, Richard B.
collection PubMed
description Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine’s role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan.
format Online
Article
Text
id pubmed-7910963
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79109632021-02-28 Creatine in Health and Disease Kreider, Richard B. Stout, Jeffery R. Nutrients Review Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine’s role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan. MDPI 2021-01-29 /pmc/articles/PMC7910963/ /pubmed/33572884 http://dx.doi.org/10.3390/nu13020447 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kreider, Richard B.
Stout, Jeffery R.
Creatine in Health and Disease
title Creatine in Health and Disease
title_full Creatine in Health and Disease
title_fullStr Creatine in Health and Disease
title_full_unstemmed Creatine in Health and Disease
title_short Creatine in Health and Disease
title_sort creatine in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910963/
https://www.ncbi.nlm.nih.gov/pubmed/33572884
http://dx.doi.org/10.3390/nu13020447
work_keys_str_mv AT kreiderrichardb creatineinhealthanddisease
AT stoutjefferyr creatineinhealthanddisease