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Nanomaterials for Protein Delivery in Anticancer Applications

Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to re...

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Detalles Bibliográficos
Autores principales: Yau, Anne, Lee, Jinhyung, Chen, Yupeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910976/
https://www.ncbi.nlm.nih.gov/pubmed/33503889
http://dx.doi.org/10.3390/pharmaceutics13020155
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author Yau, Anne
Lee, Jinhyung
Chen, Yupeng
author_facet Yau, Anne
Lee, Jinhyung
Chen, Yupeng
author_sort Yau, Anne
collection PubMed
description Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to recently developed biologics, such as proteins, peptides, and nucleic acids. Among them, proteins have shown a series of advantages and potential in various therapeutic applications, such as introducing therapeutic proteins due to genetic defects, or used as nanocarriers for anticancer agents to decelerate tumor growth or control metastasis. This review discusses the existing nanoparticle delivery systems, introducing design strategies, advantages of using each system, and possible limitations. Moreover, we will examine the intracellular delivery of different protein therapeutics, such as antibodies, antigens, and gene editing proteins into the host cells to achieve anticancer effects and cancer vaccines. Finally, we explore the current applications of protein delivery in anticancer treatments.
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spelling pubmed-79109762021-02-28 Nanomaterials for Protein Delivery in Anticancer Applications Yau, Anne Lee, Jinhyung Chen, Yupeng Pharmaceutics Review Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to recently developed biologics, such as proteins, peptides, and nucleic acids. Among them, proteins have shown a series of advantages and potential in various therapeutic applications, such as introducing therapeutic proteins due to genetic defects, or used as nanocarriers for anticancer agents to decelerate tumor growth or control metastasis. This review discusses the existing nanoparticle delivery systems, introducing design strategies, advantages of using each system, and possible limitations. Moreover, we will examine the intracellular delivery of different protein therapeutics, such as antibodies, antigens, and gene editing proteins into the host cells to achieve anticancer effects and cancer vaccines. Finally, we explore the current applications of protein delivery in anticancer treatments. MDPI 2021-01-25 /pmc/articles/PMC7910976/ /pubmed/33503889 http://dx.doi.org/10.3390/pharmaceutics13020155 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yau, Anne
Lee, Jinhyung
Chen, Yupeng
Nanomaterials for Protein Delivery in Anticancer Applications
title Nanomaterials for Protein Delivery in Anticancer Applications
title_full Nanomaterials for Protein Delivery in Anticancer Applications
title_fullStr Nanomaterials for Protein Delivery in Anticancer Applications
title_full_unstemmed Nanomaterials for Protein Delivery in Anticancer Applications
title_short Nanomaterials for Protein Delivery in Anticancer Applications
title_sort nanomaterials for protein delivery in anticancer applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910976/
https://www.ncbi.nlm.nih.gov/pubmed/33503889
http://dx.doi.org/10.3390/pharmaceutics13020155
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