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PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer

Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast cancer (BC) remains controversial and its prevalence and prognostic value in breast cancer from Middle Eastern ethnicity is la...

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Autores principales: Parvathareddy, Sandeep Kumar, Siraj, Abdul K., Ahmed, Saeeda O., Ghazwani, Laila Omar, Aldughaither, Saud M., Al-Dayel, Fouad, Tulbah, Asma, Ajarim, Dahish, Al-Kuraya, Khawla S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910988/
https://www.ncbi.nlm.nih.gov/pubmed/33503961
http://dx.doi.org/10.3390/cells10020229
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author Parvathareddy, Sandeep Kumar
Siraj, Abdul K.
Ahmed, Saeeda O.
Ghazwani, Laila Omar
Aldughaither, Saud M.
Al-Dayel, Fouad
Tulbah, Asma
Ajarim, Dahish
Al-Kuraya, Khawla S.
author_facet Parvathareddy, Sandeep Kumar
Siraj, Abdul K.
Ahmed, Saeeda O.
Ghazwani, Laila Omar
Aldughaither, Saud M.
Al-Dayel, Fouad
Tulbah, Asma
Ajarim, Dahish
Al-Kuraya, Khawla S.
author_sort Parvathareddy, Sandeep Kumar
collection PubMed
description Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast cancer (BC) remains controversial and its prevalence and prognostic value in breast cancer from Middle Eastern ethnicity is lacking. A total of 1003 unselected Middle Eastern breast cancers were analyzed for PD-L1 expression using immunohistochemistry. PD-L1 expression, seen in 32.8% (329/1003) of cases, was significantly associated with poor prognostic indicators such as younger patients, high-grade tumors, estrogen-receptor (ER)-negative, progesterone-receptor (PR)-negative, and triple-negative breast cancers (TNBC) as well as high Ki-67 index. We also found a significant association between PD-L1 expression and deficient mismatch repair protein expression. No association was found between PD-L1 expression and clinical outcome. However, on further subgroup analysis, PD-L1 expression was found to be an independent marker for favorable overall survival and recurrence-free survival in TNBC. In conclusion, we demonstrated strong association between PD-L1 and mismatch repair deficiency in Middle Eastern BC patients and that PD-L1 overexpression in tumor cells was an independent prognostic marker in TNBCs from Middle Eastern ethnicity. Overall, these findings might help in the development of more appropriate treatment strategies for BC in Middle Eastern population.
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spelling pubmed-79109882021-02-28 PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer Parvathareddy, Sandeep Kumar Siraj, Abdul K. Ahmed, Saeeda O. Ghazwani, Laila Omar Aldughaither, Saud M. Al-Dayel, Fouad Tulbah, Asma Ajarim, Dahish Al-Kuraya, Khawla S. Cells Article Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast cancer (BC) remains controversial and its prevalence and prognostic value in breast cancer from Middle Eastern ethnicity is lacking. A total of 1003 unselected Middle Eastern breast cancers were analyzed for PD-L1 expression using immunohistochemistry. PD-L1 expression, seen in 32.8% (329/1003) of cases, was significantly associated with poor prognostic indicators such as younger patients, high-grade tumors, estrogen-receptor (ER)-negative, progesterone-receptor (PR)-negative, and triple-negative breast cancers (TNBC) as well as high Ki-67 index. We also found a significant association between PD-L1 expression and deficient mismatch repair protein expression. No association was found between PD-L1 expression and clinical outcome. However, on further subgroup analysis, PD-L1 expression was found to be an independent marker for favorable overall survival and recurrence-free survival in TNBC. In conclusion, we demonstrated strong association between PD-L1 and mismatch repair deficiency in Middle Eastern BC patients and that PD-L1 overexpression in tumor cells was an independent prognostic marker in TNBCs from Middle Eastern ethnicity. Overall, these findings might help in the development of more appropriate treatment strategies for BC in Middle Eastern population. MDPI 2021-01-25 /pmc/articles/PMC7910988/ /pubmed/33503961 http://dx.doi.org/10.3390/cells10020229 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parvathareddy, Sandeep Kumar
Siraj, Abdul K.
Ahmed, Saeeda O.
Ghazwani, Laila Omar
Aldughaither, Saud M.
Al-Dayel, Fouad
Tulbah, Asma
Ajarim, Dahish
Al-Kuraya, Khawla S.
PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
title PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
title_full PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
title_fullStr PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
title_full_unstemmed PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
title_short PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
title_sort pd-l1 protein expression in middle eastern breast cancer predicts favorable outcome in triple-negative breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910988/
https://www.ncbi.nlm.nih.gov/pubmed/33503961
http://dx.doi.org/10.3390/cells10020229
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