Cargando…
PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast cancer (BC) remains controversial and its prevalence and prognostic value in breast cancer from Middle Eastern ethnicity is la...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910988/ https://www.ncbi.nlm.nih.gov/pubmed/33503961 http://dx.doi.org/10.3390/cells10020229 |
_version_ | 1783656241167335424 |
---|---|
author | Parvathareddy, Sandeep Kumar Siraj, Abdul K. Ahmed, Saeeda O. Ghazwani, Laila Omar Aldughaither, Saud M. Al-Dayel, Fouad Tulbah, Asma Ajarim, Dahish Al-Kuraya, Khawla S. |
author_facet | Parvathareddy, Sandeep Kumar Siraj, Abdul K. Ahmed, Saeeda O. Ghazwani, Laila Omar Aldughaither, Saud M. Al-Dayel, Fouad Tulbah, Asma Ajarim, Dahish Al-Kuraya, Khawla S. |
author_sort | Parvathareddy, Sandeep Kumar |
collection | PubMed |
description | Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast cancer (BC) remains controversial and its prevalence and prognostic value in breast cancer from Middle Eastern ethnicity is lacking. A total of 1003 unselected Middle Eastern breast cancers were analyzed for PD-L1 expression using immunohistochemistry. PD-L1 expression, seen in 32.8% (329/1003) of cases, was significantly associated with poor prognostic indicators such as younger patients, high-grade tumors, estrogen-receptor (ER)-negative, progesterone-receptor (PR)-negative, and triple-negative breast cancers (TNBC) as well as high Ki-67 index. We also found a significant association between PD-L1 expression and deficient mismatch repair protein expression. No association was found between PD-L1 expression and clinical outcome. However, on further subgroup analysis, PD-L1 expression was found to be an independent marker for favorable overall survival and recurrence-free survival in TNBC. In conclusion, we demonstrated strong association between PD-L1 and mismatch repair deficiency in Middle Eastern BC patients and that PD-L1 overexpression in tumor cells was an independent prognostic marker in TNBCs from Middle Eastern ethnicity. Overall, these findings might help in the development of more appropriate treatment strategies for BC in Middle Eastern population. |
format | Online Article Text |
id | pubmed-7910988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79109882021-02-28 PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer Parvathareddy, Sandeep Kumar Siraj, Abdul K. Ahmed, Saeeda O. Ghazwani, Laila Omar Aldughaither, Saud M. Al-Dayel, Fouad Tulbah, Asma Ajarim, Dahish Al-Kuraya, Khawla S. Cells Article Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast cancer (BC) remains controversial and its prevalence and prognostic value in breast cancer from Middle Eastern ethnicity is lacking. A total of 1003 unselected Middle Eastern breast cancers were analyzed for PD-L1 expression using immunohistochemistry. PD-L1 expression, seen in 32.8% (329/1003) of cases, was significantly associated with poor prognostic indicators such as younger patients, high-grade tumors, estrogen-receptor (ER)-negative, progesterone-receptor (PR)-negative, and triple-negative breast cancers (TNBC) as well as high Ki-67 index. We also found a significant association between PD-L1 expression and deficient mismatch repair protein expression. No association was found between PD-L1 expression and clinical outcome. However, on further subgroup analysis, PD-L1 expression was found to be an independent marker for favorable overall survival and recurrence-free survival in TNBC. In conclusion, we demonstrated strong association between PD-L1 and mismatch repair deficiency in Middle Eastern BC patients and that PD-L1 overexpression in tumor cells was an independent prognostic marker in TNBCs from Middle Eastern ethnicity. Overall, these findings might help in the development of more appropriate treatment strategies for BC in Middle Eastern population. MDPI 2021-01-25 /pmc/articles/PMC7910988/ /pubmed/33503961 http://dx.doi.org/10.3390/cells10020229 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Parvathareddy, Sandeep Kumar Siraj, Abdul K. Ahmed, Saeeda O. Ghazwani, Laila Omar Aldughaither, Saud M. Al-Dayel, Fouad Tulbah, Asma Ajarim, Dahish Al-Kuraya, Khawla S. PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer |
title | PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer |
title_full | PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer |
title_fullStr | PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer |
title_full_unstemmed | PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer |
title_short | PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer |
title_sort | pd-l1 protein expression in middle eastern breast cancer predicts favorable outcome in triple-negative breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910988/ https://www.ncbi.nlm.nih.gov/pubmed/33503961 http://dx.doi.org/10.3390/cells10020229 |
work_keys_str_mv | AT parvathareddysandeepkumar pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT sirajabdulk pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT ahmedsaeedao pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT ghazwanilailaomar pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT aldughaithersaudm pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT aldayelfouad pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT tulbahasma pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT ajarimdahish pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer AT alkurayakhawlas pdl1proteinexpressioninmiddleeasternbreastcancerpredictsfavorableoutcomeintriplenegativebreastcancer |