Cargando…

PD-L1 Expression Is Associated with Deficient Mismatch Repair and Poor Prognosis in Middle Eastern Colorectal Cancers

Several clinical trials are investigating the use of immune-targeted therapy with Programmed death ligand-1 (PD-L1) inhibitors for colorectal cancer (CRC), with promising results for patients with mismatch repair (MMR) deficiency or metastatic CRC. However, the prognostic significance of PD-L1 expre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siraj, Abdul K., Parvathareddy, Sandeep Kumar, Annaiyappanaidu, Padmanaban, Haqawi, Wael, Al-Rasheed, Maha, AlManea, Hadeel M., AlHussaini, Hussah F., Al-Dayel, Fouad, Al-Kuraya, Khawla S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911042/ https://www.ncbi.nlm.nih.gov/pubmed/33530623 http://dx.doi.org/10.3390/jpm11020073

Ejemplares similares

Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer
por: Siraj, Abdul K., et al.
Publicado: (2021)

PD-L1 Expression Is an Independent Marker for Lymph Node Metastasis in Middle Eastern Endometrial Cancer
por: Siraj, Abdul K., et al.
Publicado: (2021)

Tumor size is an independent negative prognostic factor for event free survival in children with differentiated thyroid cancer
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2022)

X-linked inhibitor of apoptosis protein (XIAP) predicts disease-free survival in BRAFV600E mutant papillary thyroid carcinoma in middle eastern patients
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2022)

Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2020)

Predictive risk factors for distant metastasis in pediatric differentiated thyroid cancer from Saudi Arabia
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2023)

Risk Factors for Cervical Lymph Node Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2022)

Bilateral multifocality is an independent predictor of patients’ outcome in Middle Eastern papillary thyroid carcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2023)

Male Sex Is an Independent Predictor of Recurrence-Free Survival in Middle Eastern Papillary Thyroid Carcinoma
por: Siraj, Abdul K., et al.
Publicado: (2022)

Loss of CDH16 expression is a strong independent predictor for lymph node metastasis in Middle Eastern papillary thyroid cancer
por: Siraj, Abdul K., et al.
Publicado: (2023)

Cyclin-dependent kinase 9 (CDK9) predicts recurrence in Middle Eastern epithelial ovarian cancer
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2021)

Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer
por: Siraj, Abdul Khalid, et al.
Publicado: (2022)

High Expression of Cyclin D1 is an Independent Marker for Favorable Prognosis in Middle Eastern Breast Cancer
por: Siraj, Abdul K, et al.
Publicado: (2021)

Lynch Syndrome Identification in Saudi Cohort of Endometrial Cancer Patients Screened by Universal Approach
por: Bu, Rong, et al.
Publicado: (2022)

Clonal Evolution and Timing of Metastatic Colorectal Cancer
por: Siraj, Sarah, et al.
Publicado: (2020)

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma
por: Siraj, Abdul K, et al.
Publicado: (2014)

PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients
por: Siraj, Abdul K., et al.
Publicado: (2023)

SUN-132 KLF5 Is a Poor Prognostic Marker and Therapeutic Target for Middle Eastern Papillary Thyroid Carcinoma
por: Al-Kuraya, Khawla S, et al.
Publicado: (2020)

PD-L1 Is an Independent Prognostic Marker in Middle Eastern PTC and Its Expression Is Upregulated by BRAFV600E Mutation
por: Siraj, Abdul K., et al.
Publicado: (2021)

Annual Hazard Rate of Recurrence in Middle Eastern Papillary Thyroid Cancer over a Long-Term Follow-Up
por: Siraj, Abdul K., et al.
Publicado: (2020)

TERT Promoter Mutations Are an Independent Predictor of Distant Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2022)

Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer
por: Bu, Rong, et al.
Publicado: (2021)

Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients
por: Siraj, Abdul Khalid, et al.
Publicado: (2021)

Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2021)

Risk Factors for Central Lymph Node Metastases and Benefit of Prophylactic Central Lymph Node Dissection in Middle Eastern Patients With cN0 Papillary Thyroid Carcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2022)

Microscopic Extrathyroidal Extension Results in Increased Rate of Tumor Recurrence and Is an Independent Predictor of Patient’s Outcome in Middle Eastern Papillary Thyroid Carcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2021)

Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity
por: Bu, Rong, et al.
Publicado: (2023)

Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients
por: Siraj, Abdul K., et al.
Publicado: (2021)

Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment
por: Siraj, Abdul Khalid, et al.
Publicado: (2018)

PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2021)

Overexpression of the pro‐protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF/MEK signaling
por: Poyil, Pratheesh Kumar, et al.
Publicado: (2023)

Whole Exome-Wide Association Identifies Rare Variants in GALNT9 Associated with Middle Eastern Papillary Thyroid Carcinoma Risk
por: Bu, Rong, et al.
Publicado: (2023)

FoxM1 is an independent poor prognostic marker and therapeutic target for advanced Middle Eastern breast cancer
por: Siraj, Abdul Khalid, et al.
Publicado: (2018)

Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region
por: Siraj, Abdul K., et al.
Publicado: (2019)

FoxM1 and β-catenin predicts aggressiveness in Middle Eastern ovarian cancer and their co-targeting impairs the growth of ovarian cancer cells
por: Pratheeshkumar, Poyil, et al.
Publicado: (2017)

The study of Lynch syndrome in a special population reveals a strong founder effect and an unusual mutational mechanism in familial adenomatous polyposis
por: Siraj, Abdul K, et al.
Publicado: (2020)

CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells
por: Pratheeshkumar, Poyil, et al.
Publicado: (2021)

Polymorphisms of selected Xenobiotic Genes contribute to the development of Papillary Thyroid Cancer susceptibility in Middle Eastern population
por: Siraj, Abdul K, et al.
Publicado: (2008)

Lymph node ratio is superior to AJCC N stage for predicting recurrence in papillary thyroid carcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2022)

Prognostic Value and Function of KLF5 in Papillary Thyroid Cancer
por: Pratheeshkumar, Poyil, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g0j30p77t1at9ikdptjplc1jlr