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Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies

We have previously reported that the leaf extract of Albizia anthelmintica exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides deriv...

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Autores principales: Nabil, Mohamed, El Raey, Mohamed A., Abdo, Walied, Abdelfattah, Mohamed A. O., El-Shazly, Assem M., Sobeh, Mansour, Mahmoud, Mona F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911069/
https://www.ncbi.nlm.nih.gov/pubmed/33530540
http://dx.doi.org/10.3390/antiox10020176
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author Nabil, Mohamed
El Raey, Mohamed A.
Abdo, Walied
Abdelfattah, Mohamed A. O.
El-Shazly, Assem M.
Sobeh, Mansour
Mahmoud, Mona F.
author_facet Nabil, Mohamed
El Raey, Mohamed A.
Abdo, Walied
Abdelfattah, Mohamed A. O.
El-Shazly, Assem M.
Sobeh, Mansour
Mahmoud, Mona F.
author_sort Nabil, Mohamed
collection PubMed
description We have previously reported that the leaf extract of Albizia anthelmintica exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work, we explored the gastroprotective effects of the leaf extract in an indomethacin-induced ulcer model and the mechanisms involved. The rats being pretreated with the tested extract (100 and 200 mg kg(−1)) significantly prevented gastric lesions by 87.4% and 92.3%, respectively, and they had no structural derangements in the gastric mucosa. The extract significantly reduced the elevated levels of IKκB, NF-κB, TNF-α, IL-6, iNOS, and lipid peroxidation; increased the reduced level of glutathione peroxidase (GPx) activity; and reduced glutathione (GSH) in the indomethacin-induced ulcer model. The protective activities of the extract were similar in most aspects to those exerted by the known anti-ulcer drug famotidine. These activities might be attributed to the anti-inflammatory and antioxidant activities, and the reduction of iNOS levels. In conclusion, Albizia anthelmintica is a potential candidate for management of gastric ulcers with antioxidant properties.
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spelling pubmed-79110692021-02-28 Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies Nabil, Mohamed El Raey, Mohamed A. Abdo, Walied Abdelfattah, Mohamed A. O. El-Shazly, Assem M. Sobeh, Mansour Mahmoud, Mona F. Antioxidants (Basel) Article We have previously reported that the leaf extract of Albizia anthelmintica exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work, we explored the gastroprotective effects of the leaf extract in an indomethacin-induced ulcer model and the mechanisms involved. The rats being pretreated with the tested extract (100 and 200 mg kg(−1)) significantly prevented gastric lesions by 87.4% and 92.3%, respectively, and they had no structural derangements in the gastric mucosa. The extract significantly reduced the elevated levels of IKκB, NF-κB, TNF-α, IL-6, iNOS, and lipid peroxidation; increased the reduced level of glutathione peroxidase (GPx) activity; and reduced glutathione (GSH) in the indomethacin-induced ulcer model. The protective activities of the extract were similar in most aspects to those exerted by the known anti-ulcer drug famotidine. These activities might be attributed to the anti-inflammatory and antioxidant activities, and the reduction of iNOS levels. In conclusion, Albizia anthelmintica is a potential candidate for management of gastric ulcers with antioxidant properties. MDPI 2021-01-26 /pmc/articles/PMC7911069/ /pubmed/33530540 http://dx.doi.org/10.3390/antiox10020176 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nabil, Mohamed
El Raey, Mohamed A.
Abdo, Walied
Abdelfattah, Mohamed A. O.
El-Shazly, Assem M.
Sobeh, Mansour
Mahmoud, Mona F.
Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies
title Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies
title_full Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies
title_fullStr Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies
title_full_unstemmed Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies
title_short Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies
title_sort gastro-protective effects of albizia anthelmintica leaf extract on indomethacin-induced gastric ulcer in wistar rats: in silico and in vivo studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911069/
https://www.ncbi.nlm.nih.gov/pubmed/33530540
http://dx.doi.org/10.3390/antiox10020176
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