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Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B–PKA–Caspase8/9 Pathway

In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum an...

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Detalles Bibliográficos
Autores principales:	Tao, Jing-Li, Zhang, Xuan, Zhou, Jia-Qi, Li, Cheng-Yu, Yang, Ming-Hui, Liu, Zhao-Jun, Zhang, Liang-Liang, Deng, Shou-Long, Zhang, Lu, Shen, Ming, Liu, Guo-Shi, Liu, Hong-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911142/ https://www.ncbi.nlm.nih.gov/pubmed/33525391 http://dx.doi.org/10.3390/antiox10020184

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