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Transcriptomic Insights into the Insect Immune Response to Nematode Infection
Insects in nature interact with a wide variety of microbial enemies including nematodes. These include entomopathogenic nematodes that contain mutualistic bacteria and together are able to infect a broad range of insects in order to complete their life cycle and multiply, filarial nematodes which ar...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911283/ https://www.ncbi.nlm.nih.gov/pubmed/33573306 http://dx.doi.org/10.3390/genes12020202 |
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author | Eleftherianos, Ioannis Heryanto, Christa |
author_facet | Eleftherianos, Ioannis Heryanto, Christa |
author_sort | Eleftherianos, Ioannis |
collection | PubMed |
description | Insects in nature interact with a wide variety of microbial enemies including nematodes. These include entomopathogenic nematodes that contain mutualistic bacteria and together are able to infect a broad range of insects in order to complete their life cycle and multiply, filarial nematodes which are vectored by mosquitoes, and other parasitic nematodes. Entomopathogenic nematodes are commonly used in biological control practices and they form excellent research tools for understanding the genetic and functional bases of nematode pathogenicity and insect anti-nematode immunity. In addition, clarifying the mechanism of transmission of filarial nematodes by mosquitoes is critical for devising strategies to reduce disease transmission in humans. In all cases and in order to achieve these goals, it is vital to determine the number and type of insect host genes which are differentially regulated during infection and encode factors with anti-nematode properties. In this respect, the use of transcriptomic approaches has proven a key step for the identification of insect molecules with anti-nematode activity. Here, we review the progress in the field of transcriptomics that deals with the insect response to nematode infection. This information is important because it will expose conserved pathways of anti-nematode immunity in humans. |
format | Online Article Text |
id | pubmed-7911283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79112832021-02-28 Transcriptomic Insights into the Insect Immune Response to Nematode Infection Eleftherianos, Ioannis Heryanto, Christa Genes (Basel) Review Insects in nature interact with a wide variety of microbial enemies including nematodes. These include entomopathogenic nematodes that contain mutualistic bacteria and together are able to infect a broad range of insects in order to complete their life cycle and multiply, filarial nematodes which are vectored by mosquitoes, and other parasitic nematodes. Entomopathogenic nematodes are commonly used in biological control practices and they form excellent research tools for understanding the genetic and functional bases of nematode pathogenicity and insect anti-nematode immunity. In addition, clarifying the mechanism of transmission of filarial nematodes by mosquitoes is critical for devising strategies to reduce disease transmission in humans. In all cases and in order to achieve these goals, it is vital to determine the number and type of insect host genes which are differentially regulated during infection and encode factors with anti-nematode properties. In this respect, the use of transcriptomic approaches has proven a key step for the identification of insect molecules with anti-nematode activity. Here, we review the progress in the field of transcriptomics that deals with the insect response to nematode infection. This information is important because it will expose conserved pathways of anti-nematode immunity in humans. MDPI 2021-01-30 /pmc/articles/PMC7911283/ /pubmed/33573306 http://dx.doi.org/10.3390/genes12020202 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Eleftherianos, Ioannis Heryanto, Christa Transcriptomic Insights into the Insect Immune Response to Nematode Infection |
title | Transcriptomic Insights into the Insect Immune Response to Nematode Infection |
title_full | Transcriptomic Insights into the Insect Immune Response to Nematode Infection |
title_fullStr | Transcriptomic Insights into the Insect Immune Response to Nematode Infection |
title_full_unstemmed | Transcriptomic Insights into the Insect Immune Response to Nematode Infection |
title_short | Transcriptomic Insights into the Insect Immune Response to Nematode Infection |
title_sort | transcriptomic insights into the insect immune response to nematode infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911283/ https://www.ncbi.nlm.nih.gov/pubmed/33573306 http://dx.doi.org/10.3390/genes12020202 |
work_keys_str_mv | AT eleftherianosioannis transcriptomicinsightsintotheinsectimmuneresponsetonematodeinfection AT heryantochrista transcriptomicinsightsintotheinsectimmuneresponsetonematodeinfection |