Cargando…

Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease

The current pharmacological agents advised for the management of diabetes as well as cardiovascular and hepatic diseases are subject to numerous studies for safety and efficacy. Therefore, it is worth looking into alternative therapeutic aids such as natural products of medicinal plants. By a broad...

Descripción completa

Detalles Bibliográficos
Autores principales: Ignat, Maria Valentina, Coldea, Teodora Emilia, Salanță, Liana Claudia, Mudura, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911329/
https://www.ncbi.nlm.nih.gov/pubmed/33498684
http://dx.doi.org/10.3390/plants10020216
_version_ 1783656315843772416
author Ignat, Maria Valentina
Coldea, Teodora Emilia
Salanță, Liana Claudia
Mudura, Elena
author_facet Ignat, Maria Valentina
Coldea, Teodora Emilia
Salanță, Liana Claudia
Mudura, Elena
author_sort Ignat, Maria Valentina
collection PubMed
description The current pharmacological agents advised for the management of diabetes as well as cardiovascular and hepatic diseases are subject to numerous studies for safety and efficacy. Therefore, it is worth looking into alternative therapeutic aids such as natural products of medicinal plants. By a broad review of in vitro and in vivo studies on the various dandelion, chicory, and mulberry extracts, this work highlights their bioactive compounds and therapeutic action when used as a prevention and management aid in public health such as diabetes, cardiovascular disease, and hepatic disorders like non-alcoholic steatohepatitis. Natural products of dandelion leaves and root extracts can suppress the development of liver cancer, decrease insulin resistance, and suppress total triglyceride and cholesterol levels. Recent studies on mulberry leaves extracts indicated that they could decrease palmitic acid-induced lipotoxicity, increase total cholesterol and bile acid excretion, improve superoxide dismutase expression, and improve insulin resistance. Chicory root extracts boost satiety, reverse insulin resistance, and augment lipid metabolism thanks to their contents in chicoric acid, chlorogenic acid, and polysaccharides. Taraxacum officinale L., Morus nigra L., and Cichorium intybus L. present hepatoprotective, anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic activities and are shown to be advantageous in the management of obesity, dyslipidemia, Type 2 diabetes, and non-alcoholic fatty liver diseases. These plants are commonly available in the European spontaneous flora and more attention could be paid to their natural products.
format Online
Article
Text
id pubmed-7911329
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79113292021-02-28 Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease Ignat, Maria Valentina Coldea, Teodora Emilia Salanță, Liana Claudia Mudura, Elena Plants (Basel) Review The current pharmacological agents advised for the management of diabetes as well as cardiovascular and hepatic diseases are subject to numerous studies for safety and efficacy. Therefore, it is worth looking into alternative therapeutic aids such as natural products of medicinal plants. By a broad review of in vitro and in vivo studies on the various dandelion, chicory, and mulberry extracts, this work highlights their bioactive compounds and therapeutic action when used as a prevention and management aid in public health such as diabetes, cardiovascular disease, and hepatic disorders like non-alcoholic steatohepatitis. Natural products of dandelion leaves and root extracts can suppress the development of liver cancer, decrease insulin resistance, and suppress total triglyceride and cholesterol levels. Recent studies on mulberry leaves extracts indicated that they could decrease palmitic acid-induced lipotoxicity, increase total cholesterol and bile acid excretion, improve superoxide dismutase expression, and improve insulin resistance. Chicory root extracts boost satiety, reverse insulin resistance, and augment lipid metabolism thanks to their contents in chicoric acid, chlorogenic acid, and polysaccharides. Taraxacum officinale L., Morus nigra L., and Cichorium intybus L. present hepatoprotective, anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic activities and are shown to be advantageous in the management of obesity, dyslipidemia, Type 2 diabetes, and non-alcoholic fatty liver diseases. These plants are commonly available in the European spontaneous flora and more attention could be paid to their natural products. MDPI 2021-01-23 /pmc/articles/PMC7911329/ /pubmed/33498684 http://dx.doi.org/10.3390/plants10020216 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ignat, Maria Valentina
Coldea, Teodora Emilia
Salanță, Liana Claudia
Mudura, Elena
Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease
title Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease
title_full Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease
title_fullStr Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease
title_full_unstemmed Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease
title_short Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease
title_sort plants of the spontaneous flora with beneficial action in the management of diabetes, hepatic disorders, and cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911329/
https://www.ncbi.nlm.nih.gov/pubmed/33498684
http://dx.doi.org/10.3390/plants10020216
work_keys_str_mv AT ignatmariavalentina plantsofthespontaneousflorawithbeneficialactioninthemanagementofdiabeteshepaticdisordersandcardiovasculardisease
AT coldeateodoraemilia plantsofthespontaneousflorawithbeneficialactioninthemanagementofdiabeteshepaticdisordersandcardiovasculardisease
AT salantalianaclaudia plantsofthespontaneousflorawithbeneficialactioninthemanagementofdiabeteshepaticdisordersandcardiovasculardisease
AT muduraelena plantsofthespontaneousflorawithbeneficialactioninthemanagementofdiabeteshepaticdisordersandcardiovasculardisease