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Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease

Background and aims: lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and its complications, although data on the association with other vascular beds and the severity of atherosclerosis is limited. The aim of this study was to evaluate the association of at...

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Autores principales: Tmoyan, Narek A., Afanasieva, Olga I., Ezhov, Marat V., Klesareva, Elena A., Balakhonova, Tatiana V., Pokrovsky, Sergei N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911372/
https://www.ncbi.nlm.nih.gov/pubmed/33513851
http://dx.doi.org/10.3390/jcdd8020011
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author Tmoyan, Narek A.
Afanasieva, Olga I.
Ezhov, Marat V.
Klesareva, Elena A.
Balakhonova, Tatiana V.
Pokrovsky, Sergei N.
author_facet Tmoyan, Narek A.
Afanasieva, Olga I.
Ezhov, Marat V.
Klesareva, Elena A.
Balakhonova, Tatiana V.
Pokrovsky, Sergei N.
author_sort Tmoyan, Narek A.
collection PubMed
description Background and aims: lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and its complications, although data on the association with other vascular beds and the severity of atherosclerosis is limited. The aim of this study was to evaluate the association of atherosclerosis of various vascular beds with Lp(a), as well as its autoantibodies and generalized inflammatory markers. Material and methods: this study included 1288 adult patients with clinical and imaging examination of three vascular beds (coronary, carotid, and lower limb arteries). Patients were categorized according to the number of affected vascular beds (with at least one atherosclerotic stenosis ≥50%): 0 (n = 339), 1 (n = 470), 2 (n = 315), 3 (n = 164). We assessed blood cell count, lipid profile, C-reactive protein, circulating immune complexes, Lp(a), and its autoantibodies. Results: the number of affected vascular beds was associated with an increasing level of Lp(a) and a lower level of IgM autoantibodies to Lp(a). Hyperlipoproteinemia(a) (Lp(a) ≥ 30 mg/dL) was detected more frequently in patients with atherosclerosis. In logistic regression analysis adjusted for age, sex, hypertension, type 2 diabetes, and smoking, an elevated Lp(a) level was independently associated with stenotic atherosclerosis and lesion severity. There was a positive association of the number of affected vascular beds with C-reactive protein (r = 0.21, p < 0.01) and a negative association with circulating immune complexes (r = −0.29, p < 0.01). The neutrophil-to-lymphocyte ratio was significantly higher and the lymphocyte-to-monocyte ratio was significantly lower in patients with atherosclerosis compared to the controls (p < 0.01). Conclusion: Lp(a), C-reactive protein, circulating immune complexes, and neutrophil-to-lymphocyte ratio are associated with the stenotic atherosclerosis of different vascular beds. Lp(a) levels increase and IgM autoantibodies to Lp(a) decrease with the number of affected vascular beds.
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spelling pubmed-79113722021-02-28 Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease Tmoyan, Narek A. Afanasieva, Olga I. Ezhov, Marat V. Klesareva, Elena A. Balakhonova, Tatiana V. Pokrovsky, Sergei N. J Cardiovasc Dev Dis Article Background and aims: lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and its complications, although data on the association with other vascular beds and the severity of atherosclerosis is limited. The aim of this study was to evaluate the association of atherosclerosis of various vascular beds with Lp(a), as well as its autoantibodies and generalized inflammatory markers. Material and methods: this study included 1288 adult patients with clinical and imaging examination of three vascular beds (coronary, carotid, and lower limb arteries). Patients were categorized according to the number of affected vascular beds (with at least one atherosclerotic stenosis ≥50%): 0 (n = 339), 1 (n = 470), 2 (n = 315), 3 (n = 164). We assessed blood cell count, lipid profile, C-reactive protein, circulating immune complexes, Lp(a), and its autoantibodies. Results: the number of affected vascular beds was associated with an increasing level of Lp(a) and a lower level of IgM autoantibodies to Lp(a). Hyperlipoproteinemia(a) (Lp(a) ≥ 30 mg/dL) was detected more frequently in patients with atherosclerosis. In logistic regression analysis adjusted for age, sex, hypertension, type 2 diabetes, and smoking, an elevated Lp(a) level was independently associated with stenotic atherosclerosis and lesion severity. There was a positive association of the number of affected vascular beds with C-reactive protein (r = 0.21, p < 0.01) and a negative association with circulating immune complexes (r = −0.29, p < 0.01). The neutrophil-to-lymphocyte ratio was significantly higher and the lymphocyte-to-monocyte ratio was significantly lower in patients with atherosclerosis compared to the controls (p < 0.01). Conclusion: Lp(a), C-reactive protein, circulating immune complexes, and neutrophil-to-lymphocyte ratio are associated with the stenotic atherosclerosis of different vascular beds. Lp(a) levels increase and IgM autoantibodies to Lp(a) decrease with the number of affected vascular beds. MDPI 2021-01-27 /pmc/articles/PMC7911372/ /pubmed/33513851 http://dx.doi.org/10.3390/jcdd8020011 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tmoyan, Narek A.
Afanasieva, Olga I.
Ezhov, Marat V.
Klesareva, Elena A.
Balakhonova, Tatiana V.
Pokrovsky, Sergei N.
Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease
title Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease
title_full Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease
title_fullStr Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease
title_full_unstemmed Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease
title_short Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease
title_sort lipoprotein(a), immunity, and inflammation in polyvascular atherosclerotic disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911372/
https://www.ncbi.nlm.nih.gov/pubmed/33513851
http://dx.doi.org/10.3390/jcdd8020011
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