Cargando…

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling

Extracellular signal-regulated kinase (ERK5) is an essential regulator of cancer progression, tumor relapse, and poor patient survival. Epithelial to mesenchymal transition (EMT) is a complex oncogenic process, which drives cell invasion, stemness, and metastases. Activators of ERK5, including mitog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhatt, Akshita B., Patel, Saloni, Matossian, Margarite D., Ucar, Deniz A., Miele, Lucio, Burow, Matthew E., Flaherty, Patrick T., Cavanaugh, Jane E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911413/ https://www.ncbi.nlm.nih.gov/pubmed/33572742 http://dx.doi.org/10.3390/biom11020183

Ejemplares similares

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer
por: Bhatt, Akshita B., et al.
Publicado: (2021)

Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer
por: Matossian, Margarite D., et al.
Publicado: (2021)

ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer
por: Hoang, Van T., et al.
Publicado: (2020)

Novel Diphenylamine Analogs Induce Mesenchymal to Epithelial Transition in Triple Negative Breast Cancer
por: Bhatt, Akshita B., et al.
Publicado: (2019)

Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways
por: Hossain, Fokhrul, et al.
Publicado: (2018)

Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor
por: Chang, Tiffany C., et al.
Publicado: (2020)

Correction: Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor
por: Chang, Tiffany C., et al.
Publicado: (2021)

Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer
por: Hossain, Fokhrul, et al.
Publicado: (2023)

Panobinostat suppresses the mesenchymal phenotype in a novel claudin-low triple negative patient-derived breast cancer model
por: Matossian, Margarite D., et al.
Publicado: (2018)

Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy
por: Dong, Shengli, et al.
Publicado: (2023)

Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells
por: Matossian, Margarite D., et al.
Publicado: (2021)

Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models
por: Sabol, Rachel A., et al.
Publicado: (2019)

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
por: Espinoza, Ingrid, et al.
Publicado: (2013)

KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition
por: Rao, Chaitra, et al.
Publicado: (2021)

ERK signalling modulates epigenome to drive epithelial to mesenchymal transition
por: Navandar, Mohit, et al.
Publicado: (2017)

Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment
por: Nguyen, Khoa, et al.
Publicado: (2021)

Ceritinib is a novel triple negative breast cancer therapeutic agent
por: Dong, Shengli, et al.
Publicado: (2022)

ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models
por: Guo, Shanchun, et al.
Publicado: (2018)

Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma
por: Chen, Lu, et al.
Publicado: (2019)

Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer
por: Matossian, Margarite D., et al.
Publicado: (2020)

Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes
por: Matossian, Margarite D., et al.
Publicado: (2017)

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model
por: Matossian, Margarite D., et al.
Publicado: (2019)

ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial–mesenchymal transition
por: Liang, Zhaofeng, et al.
Publicado: (2015)

Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue
por: Gurrala, Rakesh, et al.
Publicado: (2021)

Dusp6 Inhibits Epithelial-mesenchymal Transition in Endometrial Adenocarcinoma Via ERK Signaling Pathway
por: Fan, Ming-Jun, et al.
Publicado: (2019)

Spred2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by impairing ERK signaling
por: Wang, Hao, et al.
Publicado: (2020)

Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways
por: Ma, Wenqiong, et al.
Publicado: (2023)

Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transition
por: ANTOON, JAMES W., et al.
Publicado: (2013)

Proteomic analysis of tumor necrosis factor-α resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype
por: Zhou, Changhua, et al.
Publicado: (2008)

Altered Death Receptor Signaling Promotes Epithelial-to-Mesenchymal Transition and Acquired Chemoresistance
por: Antoon, James W., et al.
Publicado: (2012)

Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1
por: Carriere, Patrick P., et al.
Publicado: (2015)

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis
por: Ding, Qiang, et al.
Publicado: (2014)

Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer
por: Ding, Chenbo, et al.
Publicado: (2016)

Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities
por: Choi, Hye Yeon, et al.
Publicado: (2019)

TBX2 overexpression promotes proliferation and invasion through epithelial-mesenchymal transition and ERK signaling pathway
por: Liu, Xingyu, et al.
Publicado: (2019)

Paxillin knockdown suppresses metastasis and epithelial-mesenchymal transition in colorectal cancer via the ERK signalling pathway
por: Wen, Long, et al.
Publicado: (2020)

ERK inactivation enhances stemness of NSCLC cells via promoting Slug-mediated epithelial-to-mesenchymal transition
por: Cai, Shurui, et al.
Publicado: (2022)

Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling
por: Wu, Jianguo, et al.
Publicado: (2016)

Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways
por: Sadek, Khaled W., et al.
Publicado: (2018)

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway
por: Wu, Qiong, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_un94gfvlconoa493m2j7iqel57