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Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic
Background: The first wave of COVID-19 pandemic may have significantly impacted antimicrobial consumption in hospitals. The objective of this study was to assess the evolution of antimicrobial consumption during this period. Methods: A retrospective quasi-experimental before–after study was conducte...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911440/ https://www.ncbi.nlm.nih.gov/pubmed/33573070 http://dx.doi.org/10.3390/antibiotics10020132 |
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author | Grau, Santiago Echeverria-Esnal, Daniel Gómez-Zorrilla, Silvia Navarrete-Rouco, Maria Eugenia Masclans, Joan Ramon Espona, Merce Gracia-Arnillas, Maria Pilar Duran, Xavier Comas, Merce Horcajada, Juan Pablo Ferrández, Olivia |
author_facet | Grau, Santiago Echeverria-Esnal, Daniel Gómez-Zorrilla, Silvia Navarrete-Rouco, Maria Eugenia Masclans, Joan Ramon Espona, Merce Gracia-Arnillas, Maria Pilar Duran, Xavier Comas, Merce Horcajada, Juan Pablo Ferrández, Olivia |
author_sort | Grau, Santiago |
collection | PubMed |
description | Background: The first wave of COVID-19 pandemic may have significantly impacted antimicrobial consumption in hospitals. The objective of this study was to assess the evolution of antimicrobial consumption during this period. Methods: A retrospective quasi-experimental before–after study was conducted in a Spanish tertiary care hospital. The study compared two periods: pre-pandemic, from January 2018 to February 2020, and during the COVID-19 pandemic from March to June 2020. Antimicrobial consumption was analyzed monthly as defined daily doses (DDD)/100 bed-days and overall hospital and ICU consumption were evaluated. Results: An increase in the hospital consumption was noticed. Although only ceftaroline achieved statistical significance (p = 0.014), a rise was observed in most of the studied antimicrobials. A clear temporal pattern was detected. While an increase in ceftriaxone and azithromycin was observed during March, an increment in the consumption of daptomycin, carbapenems, linezolid, ceftaroline, novel cephalosporin/β-lactamase inhibitors or triazoles during April–May was noticed. In the ICU, these findings were more evident, namely ceftriaxone (p = 0.029), carbapenems (p = 0.002), daptomycin (p = 0.002), azithromycin (p = 0.030), and linezolid (p = 0.011) but followed a similar temporal pattern. Conclusion: An increase in the antimicrobial consumption during the first wave of COVID-19 pandemic was noticed, especially in the ICU. Availability of updated protocols and antimicrobial stewardship programs are essential to optimize these outcomes. |
format | Online Article Text |
id | pubmed-7911440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79114402021-02-28 Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic Grau, Santiago Echeverria-Esnal, Daniel Gómez-Zorrilla, Silvia Navarrete-Rouco, Maria Eugenia Masclans, Joan Ramon Espona, Merce Gracia-Arnillas, Maria Pilar Duran, Xavier Comas, Merce Horcajada, Juan Pablo Ferrández, Olivia Antibiotics (Basel) Article Background: The first wave of COVID-19 pandemic may have significantly impacted antimicrobial consumption in hospitals. The objective of this study was to assess the evolution of antimicrobial consumption during this period. Methods: A retrospective quasi-experimental before–after study was conducted in a Spanish tertiary care hospital. The study compared two periods: pre-pandemic, from January 2018 to February 2020, and during the COVID-19 pandemic from March to June 2020. Antimicrobial consumption was analyzed monthly as defined daily doses (DDD)/100 bed-days and overall hospital and ICU consumption were evaluated. Results: An increase in the hospital consumption was noticed. Although only ceftaroline achieved statistical significance (p = 0.014), a rise was observed in most of the studied antimicrobials. A clear temporal pattern was detected. While an increase in ceftriaxone and azithromycin was observed during March, an increment in the consumption of daptomycin, carbapenems, linezolid, ceftaroline, novel cephalosporin/β-lactamase inhibitors or triazoles during April–May was noticed. In the ICU, these findings were more evident, namely ceftriaxone (p = 0.029), carbapenems (p = 0.002), daptomycin (p = 0.002), azithromycin (p = 0.030), and linezolid (p = 0.011) but followed a similar temporal pattern. Conclusion: An increase in the antimicrobial consumption during the first wave of COVID-19 pandemic was noticed, especially in the ICU. Availability of updated protocols and antimicrobial stewardship programs are essential to optimize these outcomes. MDPI 2021-01-29 /pmc/articles/PMC7911440/ /pubmed/33573070 http://dx.doi.org/10.3390/antibiotics10020132 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Grau, Santiago Echeverria-Esnal, Daniel Gómez-Zorrilla, Silvia Navarrete-Rouco, Maria Eugenia Masclans, Joan Ramon Espona, Merce Gracia-Arnillas, Maria Pilar Duran, Xavier Comas, Merce Horcajada, Juan Pablo Ferrández, Olivia Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic |
title | Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic |
title_full | Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic |
title_fullStr | Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic |
title_full_unstemmed | Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic |
title_short | Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic |
title_sort | evolution of antimicrobial consumption during the first wave of covid-19 pandemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911440/ https://www.ncbi.nlm.nih.gov/pubmed/33573070 http://dx.doi.org/10.3390/antibiotics10020132 |
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