Cargando…

Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs

Nucleic acid and genetic medicines are increasingly being developed, owing to their potential to treat a variety of intractable diseases. A comprehensive understanding of the in vivo fate of these agents is vital for the rational design, discovery, and fast and straightforward development of the dru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fumoto, Shintaro, Yamamoto, Tsuyoshi, Okami, Kazuya, Maemura, Yuina, Terada, Chisato, Yamayoshi, Asako, Nishida, Koyo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911509/ https://www.ncbi.nlm.nih.gov/pubmed/33530309 http://dx.doi.org/10.3390/pharmaceutics13020159

Ejemplares similares

Three-Dimensional Imaging of the Intracellular Fate of Plasmid DNA and Transgene Expression: ZsGreen1 and Tissue Clearing Method CUBIC Are an Optimal Combination for Multicolor Deep Imaging in Murine Tissues
por: Fumoto, Shintaro, et al.
Publicado: (2016)

Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules
por: Terada, Chisato, et al.
Publicado: (2022)

Interaction of Lipoplex with Albumin Enhances Gene Expression in Hepatitis Mice
por: Yoshikawa, Naoki, et al.
Publicado: (2020)

Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs
por: Oyama, Shota, et al.
Publicado: (2021)

Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides
por: Wada, Fumito, et al.
Publicado: (2021)

Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation
por: Hu, Die, et al.
Publicado: (2022)

Application of Direct Sonoporation from a Defined Surface Area of the Peritoneum: Evaluation of Transfection Characteristics in Mice
por: Nishimura, Koyo, et al.
Publicado: (2019)

A pH-Adjustable Tissue Clearing Solution That Preserves Lipid Ultrastructures: Suitable Tissue Clearing Method for DDS Evaluation
por: Fumoto, Shintaro, et al.
Publicado: (2020)

Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids
por: Mikame, Yu, et al.
Publicado: (2023)

Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides
por: Yamamoto, Tsuyoshi, et al.
Publicado: (2021)

Monitoring method for transgene expression in target tissue by blood sampling
por: Kinoshita, Eriko, et al.
Publicado: (2019)

Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry
por: Terada, Chisato, et al.
Publicado: (2023)

Effective intraperitoneal gene transfection system using nanobubbles and ultrasound irradiation
por: Nishimura, Koyo, et al.
Publicado: (2017)

Suppression of Peritoneal Fibrosis by Sonoporation of Hepatocyte Growth Factor Gene-Encoding Plasmid DNA in Mice
por: Nishimura, Koyo, et al.
Publicado: (2021)

Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
por: Panigaj, Martin, et al.
Publicado: (2023)

Intracellular Fate of Spherical Nucleic Acid Nanoparticle Conjugates
por: Wu, Xiaochen A., et al.
Publicado: (2014)

The rational dimension of understanding
por: Belkoniene, Miloud
Publicado: (2022)

Recent Advances in Lipid-Based Drug Delivery
por: Nishida, Koyo
Publicado: (2021)

Rationally Designed Anti-CRISPR Nucleic Acid Inhibitors of CRISPR-Cas9
por: Barkau, Christopher L., et al.
Publicado: (2019)

Ergogenic effects of caffeine are mediated by myokines
por: Takada, Shingo, et al.
Publicado: (2022)

A Rational Approach to an Understanding of the Arthritides
por: O'Connor, D. S.
Publicado: (1934)

Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA
por: Yamayoshi, Asako, et al.
Publicado: (2020)

Editorial: Understanding and Modulating Bone and Cartilage Cell Fate for Regenerative Medicine
por: Narcisi, Roberto, et al.
Publicado: (2019)

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins
por: Vanmeert, Michiel, et al.
Publicado: (2019)

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins
por: Vanmeert, Michiel, et al.
Publicado: (2019)

Understanding biochemistry: structure and function of nucleic acids
por: Minchin, Steve, et al.
Publicado: (2019)

The Rules of Human T Cell Fate in vivo
por: Costa del Amo, Pedro, et al.
Publicado: (2020)

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages
por: Maemura, Tadashi, et al.
Publicado: (2021)

Rational Medicine
Publicado: (1951)

Patient-Derived Ex Vivo Cultures and Endpoint Assays with Surrogate Biomarkers in Functional Testing for Prediction of Therapeutic Response
por: Tsukamoto, Yoshiyuki, et al.
Publicado: (2023)

Understanding nucleic acid sensing and its therapeutic applications
por: Kong, Ling-Zu, et al.
Publicado: (2023)

A Rational Approach to Understanding and Evaluating Responsive Neurostimulation
por: Sisterson, Nathaniel D., et al.
Publicado: (2020)

Rational design of a quantitative, pH-insensitive, nucleic acid based fluorescent chloride reporter
por: Prakash, Ved, et al.
Publicado: (2016)

Melanocyte-keratinocyte interactions in vivo: the fate of melanosomes.
por: Wolff, K.
Publicado: (1973)

Effect of the structure of ginsenosides on the in vivo fate of their liposomes
por: Chen, Chen, et al.
Publicado: (2022)

Needles in Haystacks: Understanding the Success of Selective Pairing of Nucleic Acids
por: Plata, Carlos A., et al.
Publicado: (2022)

The Child as Econometrician: A Rational Model of Preference Understanding in Children
por: Lucas, Christopher G., et al.
Publicado: (2014)

Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation
por: Kawai, Mariko, et al.
Publicado: (2017)

Homœopathy and Rational Medicine
por: Dudgeon, R. E.
Publicado: (1901)

Homœopathy and Rational Medicine
Publicado: (1901)

Cannot write session to /tmp/vufind_sessions/sess_5g6e5qs4lh7hnfddmrgre4lji6