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Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study

ST-elevation myocardial infarction (STEMI) remains one of the leading causes of mortality worldwide. The identification of novel metabolic and imaging biomarkers could unveil key pathophysiological mechanisms at the molecular level and promote personalized care in patients with acute coronary syndro...

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Autores principales: Karagiannidis, Efstratios, Papazoglou, Andreas S., Stalikas, Nikolaos, Deda, Olga, Panteris, Eleftherios, Begou, Olga, Sofidis, Georgios, Moysidis, Dimitrios V., Kartas, Anastasios, Chatzinikolaou, Evangelia, Keklikoglou, Kleoniki, Bompoti, Andreana, Gika, Helen, Theodoridis, Georgios, Sianos, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911549/
https://www.ncbi.nlm.nih.gov/pubmed/33572568
http://dx.doi.org/10.3390/jpm11020089
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author Karagiannidis, Efstratios
Papazoglou, Andreas S.
Stalikas, Nikolaos
Deda, Olga
Panteris, Eleftherios
Begou, Olga
Sofidis, Georgios
Moysidis, Dimitrios V.
Kartas, Anastasios
Chatzinikolaou, Evangelia
Keklikoglou, Kleoniki
Bompoti, Andreana
Gika, Helen
Theodoridis, Georgios
Sianos, Georgios
author_facet Karagiannidis, Efstratios
Papazoglou, Andreas S.
Stalikas, Nikolaos
Deda, Olga
Panteris, Eleftherios
Begou, Olga
Sofidis, Georgios
Moysidis, Dimitrios V.
Kartas, Anastasios
Chatzinikolaou, Evangelia
Keklikoglou, Kleoniki
Bompoti, Andreana
Gika, Helen
Theodoridis, Georgios
Sianos, Georgios
author_sort Karagiannidis, Efstratios
collection PubMed
description ST-elevation myocardial infarction (STEMI) remains one of the leading causes of mortality worldwide. The identification of novel metabolic and imaging biomarkers could unveil key pathophysiological mechanisms at the molecular level and promote personalized care in patients with acute coronary syndromes. We studied 38 patients with STEMI who underwent primary percutaneous coronary intervention and thrombus aspiration. We sought to correlate serum ceramide levels with micro-CT quantified aspirated thrombus volume and relevant angiographic outcomes, including modified TIMI thrombus grade and pre- or post-procedural TIMI flow. Higher ceramide C16:0 levels were significantly but weakly correlated with larger aspirated thrombus volume (Spearman r = 0.326, p = 0.046), larger intracoronary thrombus burden (TB; p = 0.030) and worse pre- and post-procedural TIMI flow (p = 0.049 and p = 0.039, respectively). Ceramides C24:0 and C24:1 were also significantly associated with larger intracoronary TB (p = 0.008 and p = 0.001, respectively). Receiver operating characteristic analysis demonstrated that ceramides C24:0 and C24:1 could significantly predict higher intracoronary TB (area under the curve: 0.788, 95% CI: 0.629–0.946 and 0.846, 95% CI: 0.706–0.985, respectively). In conclusion, serum ceramide levels were higher among patients with larger intracoronary and aspirated TB. This suggests that quantification of serum ceramides might improve risk-stratification of patients with STEMI and facilitate an individualized approach in clinical practice.
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spelling pubmed-79115492021-02-28 Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study Karagiannidis, Efstratios Papazoglou, Andreas S. Stalikas, Nikolaos Deda, Olga Panteris, Eleftherios Begou, Olga Sofidis, Georgios Moysidis, Dimitrios V. Kartas, Anastasios Chatzinikolaou, Evangelia Keklikoglou, Kleoniki Bompoti, Andreana Gika, Helen Theodoridis, Georgios Sianos, Georgios J Pers Med Brief Report ST-elevation myocardial infarction (STEMI) remains one of the leading causes of mortality worldwide. The identification of novel metabolic and imaging biomarkers could unveil key pathophysiological mechanisms at the molecular level and promote personalized care in patients with acute coronary syndromes. We studied 38 patients with STEMI who underwent primary percutaneous coronary intervention and thrombus aspiration. We sought to correlate serum ceramide levels with micro-CT quantified aspirated thrombus volume and relevant angiographic outcomes, including modified TIMI thrombus grade and pre- or post-procedural TIMI flow. Higher ceramide C16:0 levels were significantly but weakly correlated with larger aspirated thrombus volume (Spearman r = 0.326, p = 0.046), larger intracoronary thrombus burden (TB; p = 0.030) and worse pre- and post-procedural TIMI flow (p = 0.049 and p = 0.039, respectively). Ceramides C24:0 and C24:1 were also significantly associated with larger intracoronary TB (p = 0.008 and p = 0.001, respectively). Receiver operating characteristic analysis demonstrated that ceramides C24:0 and C24:1 could significantly predict higher intracoronary TB (area under the curve: 0.788, 95% CI: 0.629–0.946 and 0.846, 95% CI: 0.706–0.985, respectively). In conclusion, serum ceramide levels were higher among patients with larger intracoronary and aspirated TB. This suggests that quantification of serum ceramides might improve risk-stratification of patients with STEMI and facilitate an individualized approach in clinical practice. MDPI 2021-01-31 /pmc/articles/PMC7911549/ /pubmed/33572568 http://dx.doi.org/10.3390/jpm11020089 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Karagiannidis, Efstratios
Papazoglou, Andreas S.
Stalikas, Nikolaos
Deda, Olga
Panteris, Eleftherios
Begou, Olga
Sofidis, Georgios
Moysidis, Dimitrios V.
Kartas, Anastasios
Chatzinikolaou, Evangelia
Keklikoglou, Kleoniki
Bompoti, Andreana
Gika, Helen
Theodoridis, Georgios
Sianos, Georgios
Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study
title Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study
title_full Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study
title_fullStr Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study
title_full_unstemmed Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study
title_short Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study
title_sort serum ceramides as prognostic biomarkers of large thrombus burden in patients with stemi: a micro-computed tomography study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911549/
https://www.ncbi.nlm.nih.gov/pubmed/33572568
http://dx.doi.org/10.3390/jpm11020089
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