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A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak

(1) Background: All deaths that occurred in a hospital of Southern Italy (“San Giuseppe Moscati” Hospital of Avellino) with medium jurisdiction (up to 425,000 citizens approximately) in the period from 9 March to 4 May 2020 were analyzed. The primary endpoint of the study was to analyze the causes o...

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Autores principales: Mascolo, Pasquale, Feola, Alessandro, Sementa, Carmen, Leone, Sebastiano, Zangani, Pierluca, Della Pietra, Bruno, Campobasso, Carlo Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911594/
https://www.ncbi.nlm.nih.gov/pubmed/33503857
http://dx.doi.org/10.3390/healthcare9020119
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author Mascolo, Pasquale
Feola, Alessandro
Sementa, Carmen
Leone, Sebastiano
Zangani, Pierluca
Della Pietra, Bruno
Campobasso, Carlo Pietro
author_facet Mascolo, Pasquale
Feola, Alessandro
Sementa, Carmen
Leone, Sebastiano
Zangani, Pierluca
Della Pietra, Bruno
Campobasso, Carlo Pietro
author_sort Mascolo, Pasquale
collection PubMed
description (1) Background: All deaths that occurred in a hospital of Southern Italy (“San Giuseppe Moscati” Hospital of Avellino) with medium jurisdiction (up to 425,000 citizens approximately) in the period from 9 March to 4 May 2020 were analyzed. The primary endpoint of the study was to analyze the causes of death in the period study. Secondary endpoints included: (1) the assessment of overall mortality in the emergency period compared with the same period of the past years (2018–2019) in the jurisdiction area; (2) the assessment of the amounts of deaths with positive and negative reverse transcription-polymerase chain reaction (RT-PCR) of nasopharyngeal and oropharyngeal swabs; (3) the frequency of clinical and radiological features consistent with Covid-19 infection in negative RT-PCR cases. (2) Methods: Patients’ information and laboratory data were collected through the computerized medical record system (My Hospital, Italy) used for the clinical management of all referring patients. Epidemiological, clinical, and radiological data were reviewed along with the results of nasopharyngeal and oropharyngeal swabs. (3) Results: From 9 March to 4 May 2020, 140 deaths (87 males, 53 females) from all causes occurred in total at “San Giuseppe Moscati” Hospital, of which 32 deaths were Covid-19 related. (4) Conclusions: The excess of mortality could be higher than the one reported in the official epidemiological surveys. False negative cases can have a distorting effect on the assessment of the real mortality rate and the excess mortality. Furthermore, many who died from Covid-19 were likely never tested or they had false negative RT-PCR results. Other victims probably died from causes indirectly related to Covid-19.
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spelling pubmed-79115942021-02-28 A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak Mascolo, Pasquale Feola, Alessandro Sementa, Carmen Leone, Sebastiano Zangani, Pierluca Della Pietra, Bruno Campobasso, Carlo Pietro Healthcare (Basel) Article (1) Background: All deaths that occurred in a hospital of Southern Italy (“San Giuseppe Moscati” Hospital of Avellino) with medium jurisdiction (up to 425,000 citizens approximately) in the period from 9 March to 4 May 2020 were analyzed. The primary endpoint of the study was to analyze the causes of death in the period study. Secondary endpoints included: (1) the assessment of overall mortality in the emergency period compared with the same period of the past years (2018–2019) in the jurisdiction area; (2) the assessment of the amounts of deaths with positive and negative reverse transcription-polymerase chain reaction (RT-PCR) of nasopharyngeal and oropharyngeal swabs; (3) the frequency of clinical and radiological features consistent with Covid-19 infection in negative RT-PCR cases. (2) Methods: Patients’ information and laboratory data were collected through the computerized medical record system (My Hospital, Italy) used for the clinical management of all referring patients. Epidemiological, clinical, and radiological data were reviewed along with the results of nasopharyngeal and oropharyngeal swabs. (3) Results: From 9 March to 4 May 2020, 140 deaths (87 males, 53 females) from all causes occurred in total at “San Giuseppe Moscati” Hospital, of which 32 deaths were Covid-19 related. (4) Conclusions: The excess of mortality could be higher than the one reported in the official epidemiological surveys. False negative cases can have a distorting effect on the assessment of the real mortality rate and the excess mortality. Furthermore, many who died from Covid-19 were likely never tested or they had false negative RT-PCR results. Other victims probably died from causes indirectly related to Covid-19. MDPI 2021-01-25 /pmc/articles/PMC7911594/ /pubmed/33503857 http://dx.doi.org/10.3390/healthcare9020119 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mascolo, Pasquale
Feola, Alessandro
Sementa, Carmen
Leone, Sebastiano
Zangani, Pierluca
Della Pietra, Bruno
Campobasso, Carlo Pietro
A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak
title A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak
title_full A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak
title_fullStr A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak
title_full_unstemmed A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak
title_short A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 Outbreak
title_sort descriptive study on causes of death in hospitalized patients in an acute general hospital of southern italy during the lockdown due to covid-19 outbreak
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911594/
https://www.ncbi.nlm.nih.gov/pubmed/33503857
http://dx.doi.org/10.3390/healthcare9020119
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