Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus

Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Re...

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Detalles Bibliográficos
Autores principales: So, Chui-Wa, Randall, Glenn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911643/
https://www.ncbi.nlm.nih.gov/pubmed/33573191
http://dx.doi.org/10.3390/v13020211
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author So, Chui-Wa
Randall, Glenn
author_facet So, Chui-Wa
Randall, Glenn
author_sort So, Chui-Wa
collection PubMed
description Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Researchers have begun adapting these cell culture models that morphologically and physiologically resemble hepatocytes in vivo to study HCV infection. This review summarizes the use of three-dimensional cell culture systems in studies of HCV infection.
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spelling pubmed-79116432021-02-28 Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus So, Chui-Wa Randall, Glenn Viruses Review Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Researchers have begun adapting these cell culture models that morphologically and physiologically resemble hepatocytes in vivo to study HCV infection. This review summarizes the use of three-dimensional cell culture systems in studies of HCV infection. MDPI 2021-01-30 /pmc/articles/PMC7911643/ /pubmed/33573191 http://dx.doi.org/10.3390/v13020211 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
So, Chui-Wa
Randall, Glenn
Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus
title Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus
title_full Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus
title_fullStr Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus
title_full_unstemmed Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus
title_short Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus
title_sort three-dimensional cell culture systems for studying hepatitis c virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911643/
https://www.ncbi.nlm.nih.gov/pubmed/33573191
http://dx.doi.org/10.3390/v13020211
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