Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond

Cardiogenic shock following acute myocardial infarction is associated with high mortality, substantially unchanged for the previous 20 years. Several approaches have been sought to achieve a therapeutic breakthrough, from myocardial revascularization strategies to the use of mechanical circulatory s...

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Detalles Bibliográficos
Autores principales: Pappalardo, Federico, Malara, Giulia, Montisci, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911652/
https://www.ncbi.nlm.nih.gov/pubmed/33513892
http://dx.doi.org/10.3390/membranes11020087
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author Pappalardo, Federico
Malara, Giulia
Montisci, Andrea
author_facet Pappalardo, Federico
Malara, Giulia
Montisci, Andrea
author_sort Pappalardo, Federico
collection PubMed
description Cardiogenic shock following acute myocardial infarction is associated with high mortality, substantially unchanged for the previous 20 years. Several approaches have been sought to achieve a therapeutic breakthrough, from myocardial revascularization strategies to the use of mechanical circulatory support. Many issues are, as yet, unresolved. Systemic inflammation seems to play a key role but is still lacking in effective therapies, and is potentially compounded by the death spiral of hypoperfusion and/or artificial devices. In this review, a multitarget approach to cardiogenic shock following acute myocardial infarction is proposed.
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spelling pubmed-79116522021-02-28 Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond Pappalardo, Federico Malara, Giulia Montisci, Andrea Membranes (Basel) Review Cardiogenic shock following acute myocardial infarction is associated with high mortality, substantially unchanged for the previous 20 years. Several approaches have been sought to achieve a therapeutic breakthrough, from myocardial revascularization strategies to the use of mechanical circulatory support. Many issues are, as yet, unresolved. Systemic inflammation seems to play a key role but is still lacking in effective therapies, and is potentially compounded by the death spiral of hypoperfusion and/or artificial devices. In this review, a multitarget approach to cardiogenic shock following acute myocardial infarction is proposed. MDPI 2021-01-27 /pmc/articles/PMC7911652/ /pubmed/33513892 http://dx.doi.org/10.3390/membranes11020087 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pappalardo, Federico
Malara, Giulia
Montisci, Andrea
Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond
title Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond
title_full Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond
title_fullStr Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond
title_full_unstemmed Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond
title_short Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond
title_sort multitarget approach to cardiogenic shock after acute myocardial infarction: extracorporeal life support (ecls) and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911652/
https://www.ncbi.nlm.nih.gov/pubmed/33513892
http://dx.doi.org/10.3390/membranes11020087
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AT montisciandrea multitargetapproachtocardiogenicshockafteracutemyocardialinfarctionextracorporeallifesupporteclsandbeyond

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