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Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide

Here, we explore the effects of prenatal alcohol exposure (PAE) in adolescence. We investigated associations between meconium ethyl glucoronide (EtG) and facial malformation. For 129 children (66/63 male/female; M = 13.3, SD = 0.32, 12–14 years), PAE was implemented by newborn meconium EtG and mater...

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Autores principales: Maschke, Janina, Roetner, Jakob, Goecke, Tamme W., Fasching, Peter A., Beckmann, Matthias W., Kratz, Oliver, Moll, Gunther H., Lenz, Bernd, Kornhuber, Johannes, Eichler, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911744/
https://www.ncbi.nlm.nih.gov/pubmed/33503863
http://dx.doi.org/10.3390/brainsci11020154
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author Maschke, Janina
Roetner, Jakob
Goecke, Tamme W.
Fasching, Peter A.
Beckmann, Matthias W.
Kratz, Oliver
Moll, Gunther H.
Lenz, Bernd
Kornhuber, Johannes
Eichler, Anna
author_facet Maschke, Janina
Roetner, Jakob
Goecke, Tamme W.
Fasching, Peter A.
Beckmann, Matthias W.
Kratz, Oliver
Moll, Gunther H.
Lenz, Bernd
Kornhuber, Johannes
Eichler, Anna
author_sort Maschke, Janina
collection PubMed
description Here, we explore the effects of prenatal alcohol exposure (PAE) in adolescence. We investigated associations between meconium ethyl glucoronide (EtG) and facial malformation. For 129 children (66/63 male/female; M = 13.3, SD = 0.32, 12–14 years), PAE was implemented by newborn meconium EtG and maternal self-reports during the third trimester. Cognitive development was operationalized by standardized scores (WISC V). The EtG cut-off values were set at ≥10 ng/g (n = 32, 24.8% EtG10+) and ≥112 ng/g (n = 20, 15.5% EtG112+). The craniofacial shape was measured using FAS Facial Photographic Analysis Software. EtG10+− and EtG112+-affected children exhibited a shorter palpebral fissure length (p = 0.031/p = 0.055). Lip circularity was smaller in EtG112+-affected children (p = 0.026). Maternal self-reports were not associated (p > 0.164). Lip circularity correlated with fluid reasoning (EtG10+ p = 0.031; EtG112+ p = 0.298) and working memory (EtG10+ p = 0.084; EtG112+ p = 0.144). The present study demonstrates visible effects of the facial phenotype in exposed adolescents. Facial malformation was associated with a child’s cognitive performance in the alcohol-exposed group. The EtG biomarker was a better predictor than maternal self-reports.
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spelling pubmed-79117442021-02-28 Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide Maschke, Janina Roetner, Jakob Goecke, Tamme W. Fasching, Peter A. Beckmann, Matthias W. Kratz, Oliver Moll, Gunther H. Lenz, Bernd Kornhuber, Johannes Eichler, Anna Brain Sci Article Here, we explore the effects of prenatal alcohol exposure (PAE) in adolescence. We investigated associations between meconium ethyl glucoronide (EtG) and facial malformation. For 129 children (66/63 male/female; M = 13.3, SD = 0.32, 12–14 years), PAE was implemented by newborn meconium EtG and maternal self-reports during the third trimester. Cognitive development was operationalized by standardized scores (WISC V). The EtG cut-off values were set at ≥10 ng/g (n = 32, 24.8% EtG10+) and ≥112 ng/g (n = 20, 15.5% EtG112+). The craniofacial shape was measured using FAS Facial Photographic Analysis Software. EtG10+− and EtG112+-affected children exhibited a shorter palpebral fissure length (p = 0.031/p = 0.055). Lip circularity was smaller in EtG112+-affected children (p = 0.026). Maternal self-reports were not associated (p > 0.164). Lip circularity correlated with fluid reasoning (EtG10+ p = 0.031; EtG112+ p = 0.298) and working memory (EtG10+ p = 0.084; EtG112+ p = 0.144). The present study demonstrates visible effects of the facial phenotype in exposed adolescents. Facial malformation was associated with a child’s cognitive performance in the alcohol-exposed group. The EtG biomarker was a better predictor than maternal self-reports. MDPI 2021-01-25 /pmc/articles/PMC7911744/ /pubmed/33503863 http://dx.doi.org/10.3390/brainsci11020154 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maschke, Janina
Roetner, Jakob
Goecke, Tamme W.
Fasching, Peter A.
Beckmann, Matthias W.
Kratz, Oliver
Moll, Gunther H.
Lenz, Bernd
Kornhuber, Johannes
Eichler, Anna
Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide
title Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide
title_full Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide
title_fullStr Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide
title_full_unstemmed Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide
title_short Prenatal Alcohol Exposure and the Facial Phenotype in Adolescents: A Study Based on Meconium Ethyl Glucuronide
title_sort prenatal alcohol exposure and the facial phenotype in adolescents: a study based on meconium ethyl glucuronide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911744/
https://www.ncbi.nlm.nih.gov/pubmed/33503863
http://dx.doi.org/10.3390/brainsci11020154
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