Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin

Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines. These compounds bear a pentapeptide, a polyketide, and an α-hydroxy ester subunit in their structure. A large n...

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Detalles Bibliográficos
Autores principales: Michon, Synthia, Cavelier, Florine, Salom-Roig, Xavier J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911808/
https://www.ncbi.nlm.nih.gov/pubmed/33498789
http://dx.doi.org/10.3390/md19020055
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author Michon, Synthia
Cavelier, Florine
Salom-Roig, Xavier J.
author_facet Michon, Synthia
Cavelier, Florine
Salom-Roig, Xavier J.
author_sort Michon, Synthia
collection PubMed
description Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines. These compounds bear a pentapeptide, a polyketide, and an α-hydroxy ester subunit in their structure. A large number of remarkable studies on aurilides have emerged since 1996. This comprehensive account summarizes the biological activities and total syntheses of natural compounds of the aurilide family as well as their synthetic analogues.
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spelling pubmed-79118082021-02-28 Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin Michon, Synthia Cavelier, Florine Salom-Roig, Xavier J. Mar Drugs Review Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines. These compounds bear a pentapeptide, a polyketide, and an α-hydroxy ester subunit in their structure. A large number of remarkable studies on aurilides have emerged since 1996. This comprehensive account summarizes the biological activities and total syntheses of natural compounds of the aurilide family as well as their synthetic analogues. MDPI 2021-01-23 /pmc/articles/PMC7911808/ /pubmed/33498789 http://dx.doi.org/10.3390/md19020055 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Michon, Synthia
Cavelier, Florine
Salom-Roig, Xavier J.
Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
title Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
title_full Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
title_fullStr Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
title_full_unstemmed Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
title_short Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
title_sort synthesis and biological activities of cyclodepsipeptides of aurilide family from marine origin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911808/
https://www.ncbi.nlm.nih.gov/pubmed/33498789
http://dx.doi.org/10.3390/md19020055
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