Cargando…

Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morales-Cano, Daniel, Barreira, Bianca, De Olaiz Navarro, Beatriz, Callejo, María, Mondejar-Parreño, Gema, Esquivel-Ruiz, Sergio, Lorente, Jose A., Moreno, Laura, Barberá, Joan A., Cogolludo, Ángel, Perez-Vizcaino, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911835/ https://www.ncbi.nlm.nih.gov/pubmed/33494520 http://dx.doi.org/10.3390/antiox10020155

Ejemplares similares

Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching
por: Chamorro, Virginia, et al.
Publicado: (2018)

Restoration of Vitamin D Levels Improves Endothelial Function and Increases TASK-Like K(+) Currents in Pulmonary Arterial Hypertension Associated with Vitamin D Deficiency
por: Callejo, Maria, et al.
Publicado: (2021)

Elevated pulmonary arterial pressure in Zucker diabetic fatty rats
por: Morales-Cano, Daniel, et al.
Publicado: (2019)

Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome
por: Callejo, María, et al.
Publicado: (2018)

Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension
por: Callejo, Maria, et al.
Publicado: (2020)

Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
por: Perez-Vizcaino, Francisco, et al.
Publicado: (2021)

Kv7 Channels in Lung Diseases
por: Mondejar-Parreño, Gema, et al.
Publicado: (2020)

Antiproliferative miR-212-5p: Promising RNA therapy for pulmonary hypertension
por: Perez-Vizcaino, Francisco, et al.
Publicado: (2022)

Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model
por: Morales-Cano, Daniel, et al.
Publicado: (2023)

Corrigendum: Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model
por: Morales-Cano, Daniel, et al.
Publicado: (2023)

The Flavonoid Quercetin Reverses Pulmonary Hypertension in Rats
por: Morales-Cano, Daniel, et al.
Publicado: (2014)

Impact of Nutrition on Pulmonary Arterial Hypertension
por: Callejo, María, et al.
Publicado: (2020)

Vitamin D Receptor Deficiency Upregulates Pulmonary Artery Kv7 Channel Activity
por: Olivencia, Miguel A., et al.
Publicado: (2023)

Pulmonary arterial dysfunction in insulin resistant obese Zucker rats
por: Moral-Sanz, Javier, et al.
Publicado: (2011)

Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion
por: Chamorro, Virginia, et al.
Publicado: (2016)

HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape
por: Medrano-Garcia, Sandra, et al.
Publicado: (2022)

Adenosine as pulmonary vasodilator in ARDS
por: Molina, JM, et al.
Publicado: (1998)

Oxygen dependence of endothelium-dependent vasodilation: importance in chronic obstructive pulmonary disease
por: Keymel, Stefanie, et al.
Publicado: (2016)

Inhaled pulmonary vasodilators in refractory hypoxemia
por: Wright, Brian J.
Publicado: (2015)

Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction
por: Cogolludo, Angel, et al.
Publicado: (2009)

Effectiveness of pulmonary vasodilators on pulmonary hypertension associated with POEMS syndrome
por: Ohashi, Kana, et al.
Publicado: (2019)

Pulmonary vasodilation in acute pulmonary embolism – a systematic review
por: Lyhne, Mads Dam, et al.
Publicado: (2020)

Efficacy and safety of oral pulmonary vasodilators in pulmonary veno‐occlusive disease
por: Nakamura, Junichi, et al.
Publicado: (2022)

Spontaneous Pulmonary Hypertension Associated With Systemic Sclerosis in P‐Selectin Glycoprotein Ligand 1–Deficient Mice
por: González‐Tajuelo, Rafael, et al.
Publicado: (2020)

Improvement of pulmonary arterial compliance by pulmonary vasodilator in pulmonary hypertension from combined pulmonary fibrosis and emphysema
por: Kusaka, Kei, et al.
Publicado: (2019)

Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension
por: Blanco, Isabel, et al.
Publicado: (2023)

Effects of Different Pulmonary Vasodilators on Arterial Saturation in a Model of Pulmonary Hypertension
por: Becker, Eva Maria, et al.
Publicado: (2013)

Pulmonary vasodilators: beyond the bounds of pulmonary arterial hypertension therapy in COVID-19
por: Franco, Veronica, et al.
Publicado: (2020)

It’s Time to Put the Term “Pulmonary Vasodilators” to Rest
por: Rubin, Lewis J.
Publicado: (2021)

Selective Use of Pulmonary Vasodilators in Patients with Fontan Physiology
por: Glenn, Thomas, et al.
Publicado: (2022)

HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction
por: Labrousse-Arias, David, et al.
Publicado: (2016)

Management of pulmonary vasodilator therapy in patients with pulmonary arterial hypertension during critical illness
por: Muzevich, Katie M, et al.
Publicado: (2014)

Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements
por: Ripeckyj, Adrian, et al.
Publicado: (2020)

Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model
por: Chandrasekharan, Praveen, et al.
Publicado: (2021)

Mirna interference in human pulmonary alveolar epithelial cells (HPAEPIC) undergoing cyclic stretch and in ex vivo ventilated and perfused rat lungs
por: Ferruelo, A, et al.
Publicado: (2015)

Dramatic and sustained responsiveness of pulmonary Langerhans cell histiocytosis-associated pulmonary hypertension to vasodilator therapy
por: May, Adam, et al.
Publicado: (2014)

Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs()
por: Takahama, Hiroko, et al.
Publicado: (2019)

Pulmonary Vasodilator Therapy in Children with Single Ventricle Physiology: Effects on Saturation and Pulmonary Arterial Pressure
por: Jeremiasen, Ida, et al.
Publicado: (2020)

Ceramide and Regulation of Vascular Tone
por: Cogolludo, Angel, et al.
Publicado: (2019)

Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries
por: Jain, Pritesh P, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_l9ukc9638qv2rcn8kr5qetnnlk