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Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020

Molecular investigation of primary HIV infections (PHI) is crucial to describe current dynamics of HIV transmission. Aim of the study was to investigate HIV transmission clusters (TC) in PHI referred during the years 2013–2020 to the National Institute for Infectious Diseases in Rome (INMI), that is...

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Autores principales: Fabeni, Lavinia, Rozera, Gabriella, Berno, Giulia, Giombini, Emanuela, Gori, Caterina, Orchi, Nicoletta, De Carli, Gabriella, Pittalis, Silvia, Puro, Vincenzo, Pinnetti, Carmela, Mondi, Annalisa, Camici, Marta, Plazzi, Maria Maddalena, Antinori, Andrea, Capobianchi, Maria Rosaria, Abbate, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911907/
https://www.ncbi.nlm.nih.gov/pubmed/33503987
http://dx.doi.org/10.3390/v13020176
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author Fabeni, Lavinia
Rozera, Gabriella
Berno, Giulia
Giombini, Emanuela
Gori, Caterina
Orchi, Nicoletta
De Carli, Gabriella
Pittalis, Silvia
Puro, Vincenzo
Pinnetti, Carmela
Mondi, Annalisa
Camici, Marta
Plazzi, Maria Maddalena
Antinori, Andrea
Capobianchi, Maria Rosaria
Abbate, Isabella
author_facet Fabeni, Lavinia
Rozera, Gabriella
Berno, Giulia
Giombini, Emanuela
Gori, Caterina
Orchi, Nicoletta
De Carli, Gabriella
Pittalis, Silvia
Puro, Vincenzo
Pinnetti, Carmela
Mondi, Annalisa
Camici, Marta
Plazzi, Maria Maddalena
Antinori, Andrea
Capobianchi, Maria Rosaria
Abbate, Isabella
author_sort Fabeni, Lavinia
collection PubMed
description Molecular investigation of primary HIV infections (PHI) is crucial to describe current dynamics of HIV transmission. Aim of the study was to investigate HIV transmission clusters (TC) in PHI referred during the years 2013–2020 to the National Institute for Infectious Diseases in Rome (INMI), that is the Lazio regional AIDS reference centre, and factors possibly associated with inclusion in TC. These were identified by phylogenetic analysis, based on population sequencing of pol; a more in depth analysis was performed on TC of B subtype, using ultra-deep sequencing (UDS) of env. Of 270 patients diagnosed with PHI during the study period, 229 were enrolled (median follow-up 168 (IQR 96–232) weeks). Median age: 39 (IQR 32–48) years; 94.8% males, 86.5% Italians, 83.4% MSM, 56.8% carrying HIV-1 subtype B. Of them, 92.6% started early treatment within a median of 4 (IQR 2–7) days after diagnosis; median time to sustained suppression was 20 (IQR 8–32) weeks. Twenty TC (median size 3, range 2–9 individuals), including 68 patients, were identified. A diagnosis prior to 2015 was the unique factor associated with inclusion in a TC. Added value of UDS was the identification of shared quasispecies components in transmission pairs within TC.
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spelling pubmed-79119072021-02-28 Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020 Fabeni, Lavinia Rozera, Gabriella Berno, Giulia Giombini, Emanuela Gori, Caterina Orchi, Nicoletta De Carli, Gabriella Pittalis, Silvia Puro, Vincenzo Pinnetti, Carmela Mondi, Annalisa Camici, Marta Plazzi, Maria Maddalena Antinori, Andrea Capobianchi, Maria Rosaria Abbate, Isabella Viruses Article Molecular investigation of primary HIV infections (PHI) is crucial to describe current dynamics of HIV transmission. Aim of the study was to investigate HIV transmission clusters (TC) in PHI referred during the years 2013–2020 to the National Institute for Infectious Diseases in Rome (INMI), that is the Lazio regional AIDS reference centre, and factors possibly associated with inclusion in TC. These were identified by phylogenetic analysis, based on population sequencing of pol; a more in depth analysis was performed on TC of B subtype, using ultra-deep sequencing (UDS) of env. Of 270 patients diagnosed with PHI during the study period, 229 were enrolled (median follow-up 168 (IQR 96–232) weeks). Median age: 39 (IQR 32–48) years; 94.8% males, 86.5% Italians, 83.4% MSM, 56.8% carrying HIV-1 subtype B. Of them, 92.6% started early treatment within a median of 4 (IQR 2–7) days after diagnosis; median time to sustained suppression was 20 (IQR 8–32) weeks. Twenty TC (median size 3, range 2–9 individuals), including 68 patients, were identified. A diagnosis prior to 2015 was the unique factor associated with inclusion in a TC. Added value of UDS was the identification of shared quasispecies components in transmission pairs within TC. MDPI 2021-01-25 /pmc/articles/PMC7911907/ /pubmed/33503987 http://dx.doi.org/10.3390/v13020176 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fabeni, Lavinia
Rozera, Gabriella
Berno, Giulia
Giombini, Emanuela
Gori, Caterina
Orchi, Nicoletta
De Carli, Gabriella
Pittalis, Silvia
Puro, Vincenzo
Pinnetti, Carmela
Mondi, Annalisa
Camici, Marta
Plazzi, Maria Maddalena
Antinori, Andrea
Capobianchi, Maria Rosaria
Abbate, Isabella
Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020
title Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020
title_full Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020
title_fullStr Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020
title_full_unstemmed Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020
title_short Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013–2020
title_sort molecular transmission dynamics of primary hiv infections in lazio region, years 2013–2020
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911907/
https://www.ncbi.nlm.nih.gov/pubmed/33503987
http://dx.doi.org/10.3390/v13020176
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