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Metabolic Control of m(6)A RNA Modification

Nutrients and metabolic pathways regulate cell growth and cell fate decisions via epigenetic modification of DNA and histones. Another key genetic material, RNA, also contains diverse chemical modifications. Among these, N(6)-methyladenosine (m(6)A) is the most prevalent and evolutionarily conserved...

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Autores principales: Kim, Joohwan, Lee, Gina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911930/
https://www.ncbi.nlm.nih.gov/pubmed/33573224
http://dx.doi.org/10.3390/metabo11020080
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author Kim, Joohwan
Lee, Gina
author_facet Kim, Joohwan
Lee, Gina
author_sort Kim, Joohwan
collection PubMed
description Nutrients and metabolic pathways regulate cell growth and cell fate decisions via epigenetic modification of DNA and histones. Another key genetic material, RNA, also contains diverse chemical modifications. Among these, N(6)-methyladenosine (m(6)A) is the most prevalent and evolutionarily conserved RNA modification. It functions in various aspects of developmental and disease states, by controlling RNA metabolism, such as stability and translation. Similar to other epigenetic processes, m(6)A modification is regulated by specific enzymes, including writers (methyltransferases), erasers (demethylases), and readers (m(6)A-binding proteins). As this is a reversible enzymatic process, metabolites can directly influence the flux of this reaction by serving as substrates and/or allosteric regulators. In this review, we will discuss recent understanding of the regulation of m(6)A RNA modification by metabolites, nutrients, and cellular metabolic pathways.
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spelling pubmed-79119302021-02-28 Metabolic Control of m(6)A RNA Modification Kim, Joohwan Lee, Gina Metabolites Review Nutrients and metabolic pathways regulate cell growth and cell fate decisions via epigenetic modification of DNA and histones. Another key genetic material, RNA, also contains diverse chemical modifications. Among these, N(6)-methyladenosine (m(6)A) is the most prevalent and evolutionarily conserved RNA modification. It functions in various aspects of developmental and disease states, by controlling RNA metabolism, such as stability and translation. Similar to other epigenetic processes, m(6)A modification is regulated by specific enzymes, including writers (methyltransferases), erasers (demethylases), and readers (m(6)A-binding proteins). As this is a reversible enzymatic process, metabolites can directly influence the flux of this reaction by serving as substrates and/or allosteric regulators. In this review, we will discuss recent understanding of the regulation of m(6)A RNA modification by metabolites, nutrients, and cellular metabolic pathways. MDPI 2021-01-30 /pmc/articles/PMC7911930/ /pubmed/33573224 http://dx.doi.org/10.3390/metabo11020080 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Joohwan
Lee, Gina
Metabolic Control of m(6)A RNA Modification
title Metabolic Control of m(6)A RNA Modification
title_full Metabolic Control of m(6)A RNA Modification
title_fullStr Metabolic Control of m(6)A RNA Modification
title_full_unstemmed Metabolic Control of m(6)A RNA Modification
title_short Metabolic Control of m(6)A RNA Modification
title_sort metabolic control of m(6)a rna modification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911930/
https://www.ncbi.nlm.nih.gov/pubmed/33573224
http://dx.doi.org/10.3390/metabo11020080
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