Cargando…

Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st tri...

Descripción completa

Detalles Bibliográficos
Autores principales: Hysaj, Ola, Marqués-Gallego, Patricia, Richard, Aline, Elgizouli, Magdeldin, Nieters, Alexandra, Quack Lötscher, Katharina C., Rohrmann, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911996/
https://www.ncbi.nlm.nih.gov/pubmed/33504033
http://dx.doi.org/10.3390/nu13020360
_version_ 1783656473200427008
author Hysaj, Ola
Marqués-Gallego, Patricia
Richard, Aline
Elgizouli, Magdeldin
Nieters, Alexandra
Quack Lötscher, Katharina C.
Rohrmann, Sabine
author_facet Hysaj, Ola
Marqués-Gallego, Patricia
Richard, Aline
Elgizouli, Magdeldin
Nieters, Alexandra
Quack Lötscher, Katharina C.
Rohrmann, Sabine
author_sort Hysaj, Ola
collection PubMed
description We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.
format Online
Article
Text
id pubmed-7911996
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79119962021-02-28 Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants Hysaj, Ola Marqués-Gallego, Patricia Richard, Aline Elgizouli, Magdeldin Nieters, Alexandra Quack Lötscher, Katharina C. Rohrmann, Sabine Nutrients Article We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D. MDPI 2021-01-25 /pmc/articles/PMC7911996/ /pubmed/33504033 http://dx.doi.org/10.3390/nu13020360 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hysaj, Ola
Marqués-Gallego, Patricia
Richard, Aline
Elgizouli, Magdeldin
Nieters, Alexandra
Quack Lötscher, Katharina C.
Rohrmann, Sabine
Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
title Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
title_full Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
title_fullStr Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
title_full_unstemmed Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
title_short Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
title_sort parathyroid hormone in pregnancy: vitamin d and other determinants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911996/
https://www.ncbi.nlm.nih.gov/pubmed/33504033
http://dx.doi.org/10.3390/nu13020360
work_keys_str_mv AT hysajola parathyroidhormoneinpregnancyvitamindandotherdeterminants
AT marquesgallegopatricia parathyroidhormoneinpregnancyvitamindandotherdeterminants
AT richardaline parathyroidhormoneinpregnancyvitamindandotherdeterminants
AT elgizoulimagdeldin parathyroidhormoneinpregnancyvitamindandotherdeterminants
AT nietersalexandra parathyroidhormoneinpregnancyvitamindandotherdeterminants
AT quacklotscherkatharinac parathyroidhormoneinpregnancyvitamindandotherdeterminants
AT rohrmannsabine parathyroidhormoneinpregnancyvitamindandotherdeterminants