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Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets

Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared...

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Detalles Bibliográficos
Autores principales: Abaci, Alperen, Gedeon, Christina, Kuna, Anna, Guvendiren, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912000/
https://www.ncbi.nlm.nih.gov/pubmed/33504009
http://dx.doi.org/10.3390/pharmaceutics13020156
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author Abaci, Alperen
Gedeon, Christina
Kuna, Anna
Guvendiren, Murat
author_facet Abaci, Alperen
Gedeon, Christina
Kuna, Anna
Guvendiren, Murat
author_sort Abaci, Alperen
collection PubMed
description Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.
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spelling pubmed-79120002021-02-28 Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets Abaci, Alperen Gedeon, Christina Kuna, Anna Guvendiren, Murat Pharmaceutics Review Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges. MDPI 2021-01-25 /pmc/articles/PMC7912000/ /pubmed/33504009 http://dx.doi.org/10.3390/pharmaceutics13020156 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abaci, Alperen
Gedeon, Christina
Kuna, Anna
Guvendiren, Murat
Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets
title Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets
title_full Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets
title_fullStr Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets
title_full_unstemmed Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets
title_short Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets
title_sort additive manufacturing of oral tablets: technologies, materials and printed tablets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912000/
https://www.ncbi.nlm.nih.gov/pubmed/33504009
http://dx.doi.org/10.3390/pharmaceutics13020156
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