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Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan
The prevalence of an epiretinal membrane (ERM) was elucidated using a dataset from a health examination program database in Japan. From the cohort database, 5042 eyes of 2552 subjects were included. The presence of an ERM, cellophane macular reflex (CMR), or preretinal macular fibrosis (PMF) was det...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912057/ https://www.ncbi.nlm.nih.gov/pubmed/33513873 http://dx.doi.org/10.3390/life11020093 |
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author | Shimizu, Hiroshi Asaoka, Ryo Omoto, Takashi Fujino, Yuri Mitaki, Shingo Onoda, Keiichi Nagai, Atsushi Yamaguchi, Shuhei Tanito, Masaki |
author_facet | Shimizu, Hiroshi Asaoka, Ryo Omoto, Takashi Fujino, Yuri Mitaki, Shingo Onoda, Keiichi Nagai, Atsushi Yamaguchi, Shuhei Tanito, Masaki |
author_sort | Shimizu, Hiroshi |
collection | PubMed |
description | The prevalence of an epiretinal membrane (ERM) was elucidated using a dataset from a health examination program database in Japan. From the cohort database, 5042 eyes of 2552 subjects were included. The presence of an ERM, cellophane macular reflex (CMR), or preretinal macular fibrosis (PMF) was detected using color fundus photographs, and crude and age-standardized prevalence were obtained. To further assess the possible risk factors of ERM, background parameters were compared between ERM+ and − groups, and multiple logistic regression analysis was performed. ERM was detected in fundus photographs of 275 eyes (eye-based prevalence of 5.5%) from 217 subjects (subject-based prevalence of 8.5%). CMR was detected in 169 eyes (3.4%) of 138 subjects (5.4%), and PMF was detected in 106 eyes (2.1%) of 97 subjects (3.8%). By univariate analyses, compared with ERM− eyes or subjects, higher Scheie’s H grade (p < 0.0001), S grade (p < 0.0001), and glaucoma prevalence (p = 0.0440) were found in ERM+ eyes, and older age (p < 0.0001), more frequent histories of hypertension (p = 0.0033) and hyperlipidemia (p = 0.0441), and more frequent uses of medication for hypertension (p = 0.0034) and hyperlipidemia (p = 0.0074), shorter body height (p = 0.0122), and higher systolic blood pressure (p = 0.0078), and thicker intimal medial thickness (p = 0.0318) were found in ERM+ subjects. By multivariate analyses, older age (p < 0.0001, estimate = 0.05/year) was the only significant factor of ERM prevalence. Age-standardized prevalence of ERM was calculated to be 2.4%, 6.7%, and 13.3% for all ages, subjects older than 40 years, and subjects older than 65 years, respectively. We reported the prevalence of ERM and its subclasses in Japanese subjects. Since its prevalence is remarkably high in older subjects, an ERM can be seen as an important cause of visual impairment in Japan and in areas of the world where individuals live to an advanced age. |
format | Online Article Text |
id | pubmed-7912057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79120572021-02-28 Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan Shimizu, Hiroshi Asaoka, Ryo Omoto, Takashi Fujino, Yuri Mitaki, Shingo Onoda, Keiichi Nagai, Atsushi Yamaguchi, Shuhei Tanito, Masaki Life (Basel) Article The prevalence of an epiretinal membrane (ERM) was elucidated using a dataset from a health examination program database in Japan. From the cohort database, 5042 eyes of 2552 subjects were included. The presence of an ERM, cellophane macular reflex (CMR), or preretinal macular fibrosis (PMF) was detected using color fundus photographs, and crude and age-standardized prevalence were obtained. To further assess the possible risk factors of ERM, background parameters were compared between ERM+ and − groups, and multiple logistic regression analysis was performed. ERM was detected in fundus photographs of 275 eyes (eye-based prevalence of 5.5%) from 217 subjects (subject-based prevalence of 8.5%). CMR was detected in 169 eyes (3.4%) of 138 subjects (5.4%), and PMF was detected in 106 eyes (2.1%) of 97 subjects (3.8%). By univariate analyses, compared with ERM− eyes or subjects, higher Scheie’s H grade (p < 0.0001), S grade (p < 0.0001), and glaucoma prevalence (p = 0.0440) were found in ERM+ eyes, and older age (p < 0.0001), more frequent histories of hypertension (p = 0.0033) and hyperlipidemia (p = 0.0441), and more frequent uses of medication for hypertension (p = 0.0034) and hyperlipidemia (p = 0.0074), shorter body height (p = 0.0122), and higher systolic blood pressure (p = 0.0078), and thicker intimal medial thickness (p = 0.0318) were found in ERM+ subjects. By multivariate analyses, older age (p < 0.0001, estimate = 0.05/year) was the only significant factor of ERM prevalence. Age-standardized prevalence of ERM was calculated to be 2.4%, 6.7%, and 13.3% for all ages, subjects older than 40 years, and subjects older than 65 years, respectively. We reported the prevalence of ERM and its subclasses in Japanese subjects. Since its prevalence is remarkably high in older subjects, an ERM can be seen as an important cause of visual impairment in Japan and in areas of the world where individuals live to an advanced age. MDPI 2021-01-27 /pmc/articles/PMC7912057/ /pubmed/33513873 http://dx.doi.org/10.3390/life11020093 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shimizu, Hiroshi Asaoka, Ryo Omoto, Takashi Fujino, Yuri Mitaki, Shingo Onoda, Keiichi Nagai, Atsushi Yamaguchi, Shuhei Tanito, Masaki Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan |
title | Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan |
title_full | Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan |
title_fullStr | Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan |
title_full_unstemmed | Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan |
title_short | Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan |
title_sort | prevalence of epiretinal membrane among subjects in a health examination program in japan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912057/ https://www.ncbi.nlm.nih.gov/pubmed/33513873 http://dx.doi.org/10.3390/life11020093 |
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