A New Perspective on the Origin of DNA Double-Strand Breaks and Its Implications for Ageing

It is estimated that 10–50 DNA double-strand breaks (DSBs) occur in a nucleated human cell per cell cycle. We reviewed the present state of knowledge and hypothesized that the currently accepted mechanisms cannot explain such high frequency of DSBs occurring daily under normal physiological conditio...

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Detalles Bibliográficos
Autores principales: Tripathy, Bhabesh Kumar, Pal, Kavita, Shabrish, Snehal, Mittra, Indraneel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912064/
https://www.ncbi.nlm.nih.gov/pubmed/33530310
http://dx.doi.org/10.3390/genes12020163

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