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Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU
Background: Trimethylaminuria (TMAU) is a rare metabolic syndrome characterized by the accumulation and the excretion of trimethylamine (TMA), a volatile diet compound produced by gut microbiota. Gut microbiota alterations are mainly involved in the secondary TMAU, whose patients show also different...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912098/ https://www.ncbi.nlm.nih.gov/pubmed/33572540 http://dx.doi.org/10.3390/jpm11020087 |
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author | Donato, Luigi Alibrandi, Simona Scimone, Concetta Castagnetti, Andrea Rao, Giacomo Sidoti, Antonina D’Angelo, Rosalia |
author_facet | Donato, Luigi Alibrandi, Simona Scimone, Concetta Castagnetti, Andrea Rao, Giacomo Sidoti, Antonina D’Angelo, Rosalia |
author_sort | Donato, Luigi |
collection | PubMed |
description | Background: Trimethylaminuria (TMAU) is a rare metabolic syndrome characterized by the accumulation and the excretion of trimethylamine (TMA), a volatile diet compound produced by gut microbiota. Gut microbiota alterations are mainly involved in the secondary TMAU, whose patients show also different psychiatric conditions. We hypothesized that the biological activity of several molecules acting as intermediate in TMA metabolic reaction might be at the basis of TMAU psychiatric comorbidities. Methods: To corroborate this hypothesis, we performed the analysis of microbiota of both psychiatric suffering secondary TMAU patients and TMAU “mentally ill” controls, comparing the alteration of metabolites produced by their gut bacteria possibly involved in neurotransmission and, in the same time, belonging to biochemical pathways leading to TMA accumulation. Results: Microbiota analyses showed that Clostridiaceae, Lachnospiraceae and Coriobacteriaceae alterations represented the bacterial families with highest variations. This results in an excessive release of serotonin and an hyperactivation of the vagus nerve that might determine the widest spectrum of psychiatric disorders shown by affected patients. These metabolites, as short chain fatty acids, lactate and neurotransmitter precursors, are also related to TMA accumulation. Conclusions: Knowledge of microbiota-gut-brain axis may become a potential new strategy for improving metabolic diseases and to treat linked psychiatric disorders. |
format | Online Article Text |
id | pubmed-7912098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79120982021-02-28 Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU Donato, Luigi Alibrandi, Simona Scimone, Concetta Castagnetti, Andrea Rao, Giacomo Sidoti, Antonina D’Angelo, Rosalia J Pers Med Article Background: Trimethylaminuria (TMAU) is a rare metabolic syndrome characterized by the accumulation and the excretion of trimethylamine (TMA), a volatile diet compound produced by gut microbiota. Gut microbiota alterations are mainly involved in the secondary TMAU, whose patients show also different psychiatric conditions. We hypothesized that the biological activity of several molecules acting as intermediate in TMA metabolic reaction might be at the basis of TMAU psychiatric comorbidities. Methods: To corroborate this hypothesis, we performed the analysis of microbiota of both psychiatric suffering secondary TMAU patients and TMAU “mentally ill” controls, comparing the alteration of metabolites produced by their gut bacteria possibly involved in neurotransmission and, in the same time, belonging to biochemical pathways leading to TMA accumulation. Results: Microbiota analyses showed that Clostridiaceae, Lachnospiraceae and Coriobacteriaceae alterations represented the bacterial families with highest variations. This results in an excessive release of serotonin and an hyperactivation of the vagus nerve that might determine the widest spectrum of psychiatric disorders shown by affected patients. These metabolites, as short chain fatty acids, lactate and neurotransmitter precursors, are also related to TMA accumulation. Conclusions: Knowledge of microbiota-gut-brain axis may become a potential new strategy for improving metabolic diseases and to treat linked psychiatric disorders. MDPI 2021-01-31 /pmc/articles/PMC7912098/ /pubmed/33572540 http://dx.doi.org/10.3390/jpm11020087 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Donato, Luigi Alibrandi, Simona Scimone, Concetta Castagnetti, Andrea Rao, Giacomo Sidoti, Antonina D’Angelo, Rosalia Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU |
title | Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU |
title_full | Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU |
title_fullStr | Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU |
title_full_unstemmed | Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU |
title_short | Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU |
title_sort | gut-brain axis cross-talk and limbic disorders as biological basis of secondary tmau |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912098/ https://www.ncbi.nlm.nih.gov/pubmed/33572540 http://dx.doi.org/10.3390/jpm11020087 |
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