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Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)

Background: This study aimed to evaluate the diagnostic added-value of serum CA-125 to the International Ovarian Tumor Analysis (IOTA) Simple Rules in order to facilitate differentiation between malignant and benign ovarian tumors before surgery. Methods: A secondary analysis of a cross-sectional co...

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Autores principales: Phinyo, Phichayut, Patumanond, Jayanton, Saenrungmuaeng, Panprapha, Chirdchim, Watcharin, Pipanmekaporn, Tanyong, Tantraworasin, Apichat, Tongsong, Theera, Tantipalakorn, Charuwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912113/
https://www.ncbi.nlm.nih.gov/pubmed/33530385
http://dx.doi.org/10.3390/diagnostics11020173
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author Phinyo, Phichayut
Patumanond, Jayanton
Saenrungmuaeng, Panprapha
Chirdchim, Watcharin
Pipanmekaporn, Tanyong
Tantraworasin, Apichat
Tongsong, Theera
Tantipalakorn, Charuwan
author_facet Phinyo, Phichayut
Patumanond, Jayanton
Saenrungmuaeng, Panprapha
Chirdchim, Watcharin
Pipanmekaporn, Tanyong
Tantraworasin, Apichat
Tongsong, Theera
Tantipalakorn, Charuwan
author_sort Phinyo, Phichayut
collection PubMed
description Background: This study aimed to evaluate the diagnostic added-value of serum CA-125 to the International Ovarian Tumor Analysis (IOTA) Simple Rules in order to facilitate differentiation between malignant and benign ovarian tumors before surgery. Methods: A secondary analysis of a cross-sectional cohort of women scheduled for surgery in Maharaj Nakorn Chiang Mai Hospital between April 2010 and March 2018 was carried out. Demographic and clinical data were prospectively collected. Histopathologic diagnosis was used as the reference standard. Logistic regression was used for development of the model. Evaluation of the diagnostic added-value was based on the increment of the area under the receiver operating characteristic curve (AuROC). Results: One hundred and forty-five women (30.3%) out of a total of 479 with adnexal masses had malignant ovarian tumors. The model that included information from the IOTA Simple Rules and serum CA-125 was significantly more superior to the model that used only information from the IOTA Simple Rules (AuROC 0.95 vs. 0.89, p < 0.001 for pre-menopause and AuROC 0.98 vs 0.83, p < 0.001 for post-menopause). Conclusions: The IOTA SR X CA-125 model showed high discriminative ability and is potentially useful as a decision tool for guiding patient referrals to oncologic specialists.
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spelling pubmed-79121132021-02-28 Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125) Phinyo, Phichayut Patumanond, Jayanton Saenrungmuaeng, Panprapha Chirdchim, Watcharin Pipanmekaporn, Tanyong Tantraworasin, Apichat Tongsong, Theera Tantipalakorn, Charuwan Diagnostics (Basel) Article Background: This study aimed to evaluate the diagnostic added-value of serum CA-125 to the International Ovarian Tumor Analysis (IOTA) Simple Rules in order to facilitate differentiation between malignant and benign ovarian tumors before surgery. Methods: A secondary analysis of a cross-sectional cohort of women scheduled for surgery in Maharaj Nakorn Chiang Mai Hospital between April 2010 and March 2018 was carried out. Demographic and clinical data were prospectively collected. Histopathologic diagnosis was used as the reference standard. Logistic regression was used for development of the model. Evaluation of the diagnostic added-value was based on the increment of the area under the receiver operating characteristic curve (AuROC). Results: One hundred and forty-five women (30.3%) out of a total of 479 with adnexal masses had malignant ovarian tumors. The model that included information from the IOTA Simple Rules and serum CA-125 was significantly more superior to the model that used only information from the IOTA Simple Rules (AuROC 0.95 vs. 0.89, p < 0.001 for pre-menopause and AuROC 0.98 vs 0.83, p < 0.001 for post-menopause). Conclusions: The IOTA SR X CA-125 model showed high discriminative ability and is potentially useful as a decision tool for guiding patient referrals to oncologic specialists. MDPI 2021-01-26 /pmc/articles/PMC7912113/ /pubmed/33530385 http://dx.doi.org/10.3390/diagnostics11020173 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Phinyo, Phichayut
Patumanond, Jayanton
Saenrungmuaeng, Panprapha
Chirdchim, Watcharin
Pipanmekaporn, Tanyong
Tantraworasin, Apichat
Tongsong, Theera
Tantipalakorn, Charuwan
Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)
title Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)
title_full Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)
title_fullStr Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)
title_full_unstemmed Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)
title_short Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)
title_sort diagnostic added-value of serum ca-125 on the iota simple rules and derivation of practical combined prediction models (iota sr x ca-125)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912113/
https://www.ncbi.nlm.nih.gov/pubmed/33530385
http://dx.doi.org/10.3390/diagnostics11020173
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