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Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review

The wound healing that follows myocardial infarction is a complex process involving multiple mechanisms, such as inflammation, angiogenesis and fibrosis. In the last two decades, the involvement of WNT signaling has been extensively studied and effects on virtually all aspects of this wound healing...

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Detalles Bibliográficos
Autores principales: Daskalopoulos, Evangelos P., Blankesteijn, W. Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912185/
https://www.ncbi.nlm.nih.gov/pubmed/33494313
http://dx.doi.org/10.3390/cells10020207
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author Daskalopoulos, Evangelos P.
Blankesteijn, W. Matthijs
author_facet Daskalopoulos, Evangelos P.
Blankesteijn, W. Matthijs
author_sort Daskalopoulos, Evangelos P.
collection PubMed
description The wound healing that follows myocardial infarction is a complex process involving multiple mechanisms, such as inflammation, angiogenesis and fibrosis. In the last two decades, the involvement of WNT signaling has been extensively studied and effects on virtually all aspects of this wound healing have been reported. However, as often is the case in a newly emerging field, inconsistent and sometimes even contradictory findings have been reported. The aim of this systematic review is to provide a comprehensive overview of studies in which the effect of interventions in WNT signaling were investigated in in vivo models of cardiac injury. To this end, we used different search engines to perform a systematic search of the literature using the key words “WNT and myocardial and infarction”. We categorized the interventions according to their place in the WNT signaling pathway (ligand, receptor, destruction complex or nuclear level). The most consistent improvements of the wound healing response were observed in studies in which the acylation of WNT proteins was inhibited by administering porcupine inhibitors, by inhibiting of the downstream glycogen synthase kinase-3β (GSK3β) and by intervening in the β-catenin-mediated gene transcription. Interestingly, in several of these studies, evidence was presented for activation of cardiomyocyte proliferation around the infarct area. These findings indicate that inhibition of WNT signaling can play a valuable role in the repair of cardiac injury, thereby improving cardiac function and preventing the development of heart failure.
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spelling pubmed-79121852021-02-28 Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review Daskalopoulos, Evangelos P. Blankesteijn, W. Matthijs Cells Review The wound healing that follows myocardial infarction is a complex process involving multiple mechanisms, such as inflammation, angiogenesis and fibrosis. In the last two decades, the involvement of WNT signaling has been extensively studied and effects on virtually all aspects of this wound healing have been reported. However, as often is the case in a newly emerging field, inconsistent and sometimes even contradictory findings have been reported. The aim of this systematic review is to provide a comprehensive overview of studies in which the effect of interventions in WNT signaling were investigated in in vivo models of cardiac injury. To this end, we used different search engines to perform a systematic search of the literature using the key words “WNT and myocardial and infarction”. We categorized the interventions according to their place in the WNT signaling pathway (ligand, receptor, destruction complex or nuclear level). The most consistent improvements of the wound healing response were observed in studies in which the acylation of WNT proteins was inhibited by administering porcupine inhibitors, by inhibiting of the downstream glycogen synthase kinase-3β (GSK3β) and by intervening in the β-catenin-mediated gene transcription. Interestingly, in several of these studies, evidence was presented for activation of cardiomyocyte proliferation around the infarct area. These findings indicate that inhibition of WNT signaling can play a valuable role in the repair of cardiac injury, thereby improving cardiac function and preventing the development of heart failure. MDPI 2021-01-21 /pmc/articles/PMC7912185/ /pubmed/33494313 http://dx.doi.org/10.3390/cells10020207 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Daskalopoulos, Evangelos P.
Blankesteijn, W. Matthijs
Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review
title Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review
title_full Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review
title_fullStr Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review
title_full_unstemmed Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review
title_short Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review
title_sort effect of interventions in wnt signaling on healing of cardiac injury: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912185/
https://www.ncbi.nlm.nih.gov/pubmed/33494313
http://dx.doi.org/10.3390/cells10020207
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