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Phage Display Technology as a Powerful Platform for Antibody Drug Discovery
Antibody drugs with a high affinity and specificity are effective and safe for intractable diseases, such as cancers and autoimmune diseases. Furthermore, they have played a central role in drug discovery, currently accounting for eight of the top 20 pharmaceutical products worldwide by sales. Forty...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912188/ https://www.ncbi.nlm.nih.gov/pubmed/33504115 http://dx.doi.org/10.3390/v13020178 |
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author | Nagano, Kazuya Tsutsumi, Yasuo |
author_facet | Nagano, Kazuya Tsutsumi, Yasuo |
author_sort | Nagano, Kazuya |
collection | PubMed |
description | Antibody drugs with a high affinity and specificity are effective and safe for intractable diseases, such as cancers and autoimmune diseases. Furthermore, they have played a central role in drug discovery, currently accounting for eight of the top 20 pharmaceutical products worldwide by sales. Forty years ago, clinical trials on antibody drugs that were thought to be a magic bullet failed, partly due to the immunogenicity of monoclonal antibodies produced in mice. The recent breakthrough in antibody drugs is largely because of the contribution of phage display technology. Here, we reviewed the importance of phage display technology as a powerful platform for antibody drug discovery from various perspectives, such as the development of human monoclonal antibodies, affinity enhancement of monoclonal antibodies, and the identification of therapeutic targets for antibody drugs. |
format | Online Article Text |
id | pubmed-7912188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79121882021-02-28 Phage Display Technology as a Powerful Platform for Antibody Drug Discovery Nagano, Kazuya Tsutsumi, Yasuo Viruses Review Antibody drugs with a high affinity and specificity are effective and safe for intractable diseases, such as cancers and autoimmune diseases. Furthermore, they have played a central role in drug discovery, currently accounting for eight of the top 20 pharmaceutical products worldwide by sales. Forty years ago, clinical trials on antibody drugs that were thought to be a magic bullet failed, partly due to the immunogenicity of monoclonal antibodies produced in mice. The recent breakthrough in antibody drugs is largely because of the contribution of phage display technology. Here, we reviewed the importance of phage display technology as a powerful platform for antibody drug discovery from various perspectives, such as the development of human monoclonal antibodies, affinity enhancement of monoclonal antibodies, and the identification of therapeutic targets for antibody drugs. MDPI 2021-01-25 /pmc/articles/PMC7912188/ /pubmed/33504115 http://dx.doi.org/10.3390/v13020178 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nagano, Kazuya Tsutsumi, Yasuo Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title | Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_full | Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_fullStr | Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_full_unstemmed | Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_short | Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_sort | phage display technology as a powerful platform for antibody drug discovery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912188/ https://www.ncbi.nlm.nih.gov/pubmed/33504115 http://dx.doi.org/10.3390/v13020178 |
work_keys_str_mv | AT naganokazuya phagedisplaytechnologyasapowerfulplatformforantibodydrugdiscovery AT tsutsumiyasuo phagedisplaytechnologyasapowerfulplatformforantibodydrugdiscovery |