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The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection
Severe acute respiratory syndrome coronavirus 2, primarily a respiratory tract virus, also affects the enteric organs. The most affected sector of the community are the retirement and nursing home elderly residents. Along their life the senescent gastrointestinal functions are deteriorating and fail...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912227/ https://www.ncbi.nlm.nih.gov/pubmed/33525368 http://dx.doi.org/10.3390/life11020097 |
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author | Lerner, Aaron McCarty, Mark F. |
author_facet | Lerner, Aaron McCarty, Mark F. |
author_sort | Lerner, Aaron |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2, primarily a respiratory tract virus, also affects the enteric organs. The most affected sector of the community are the retirement and nursing home elderly residents. Along their life the senescent gastrointestinal functions are deteriorating and failing to fully execute their digestive, absorptive, mucosal barriers, and immune protective duties. Adding the decreased motility, increased intestinal permeability, dysbiosis, morbid chronic disease background, the consumed polypharmacy enteric adverse effects to the presence of the SARS-CoV-2 host receptor along the intestinal tracts put the basis for the current hypothesis. It is hypothesized that the disadvantages and failures of the aging enteric tract contribute to the elderly morbidity and mortality during the current new coronavirus pandemic. In a more optimistic look, several nutraceuticals can prevent or restore the dysfunctional intestinal barrier functions, mainly in the elderly and potentially in those who are SARS-CoV-2 infected. |
format | Online Article Text |
id | pubmed-7912227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79122272021-02-28 The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection Lerner, Aaron McCarty, Mark F. Life (Basel) Review Severe acute respiratory syndrome coronavirus 2, primarily a respiratory tract virus, also affects the enteric organs. The most affected sector of the community are the retirement and nursing home elderly residents. Along their life the senescent gastrointestinal functions are deteriorating and failing to fully execute their digestive, absorptive, mucosal barriers, and immune protective duties. Adding the decreased motility, increased intestinal permeability, dysbiosis, morbid chronic disease background, the consumed polypharmacy enteric adverse effects to the presence of the SARS-CoV-2 host receptor along the intestinal tracts put the basis for the current hypothesis. It is hypothesized that the disadvantages and failures of the aging enteric tract contribute to the elderly morbidity and mortality during the current new coronavirus pandemic. In a more optimistic look, several nutraceuticals can prevent or restore the dysfunctional intestinal barrier functions, mainly in the elderly and potentially in those who are SARS-CoV-2 infected. MDPI 2021-01-28 /pmc/articles/PMC7912227/ /pubmed/33525368 http://dx.doi.org/10.3390/life11020097 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lerner, Aaron McCarty, Mark F. The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection |
title | The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection |
title_full | The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection |
title_fullStr | The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection |
title_full_unstemmed | The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection |
title_short | The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection |
title_sort | aging bowel dysfunction and elderly vulnerability towards covid-19 infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912227/ https://www.ncbi.nlm.nih.gov/pubmed/33525368 http://dx.doi.org/10.3390/life11020097 |
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