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The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond

The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the...

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Autores principales: Mosaoa, Rami, Kasprzyk-Pawelec, Anna, Fernandez, Harvey R., Avantaggiati, Maria Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912299/
https://www.ncbi.nlm.nih.gov/pubmed/33499062
http://dx.doi.org/10.3390/biom11020141
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author Mosaoa, Rami
Kasprzyk-Pawelec, Anna
Fernandez, Harvey R.
Avantaggiati, Maria Laura
author_facet Mosaoa, Rami
Kasprzyk-Pawelec, Anna
Fernandez, Harvey R.
Avantaggiati, Maria Laura
author_sort Mosaoa, Rami
collection PubMed
description The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the impermeable mitochondrial membrane. Citrate is central to mitochondrial metabolism and respiration and plays fundamental activities in the cytosol, serving as a metabolic substrate, an allosteric enzymatic regulator and, as the source of Acetyl-Coenzyme A, also as an epigenetic modifier. In this review, we highlight the complexity of the mechanisms of action of this transporter, describing its involvement in human diseases and the therapeutic opportunities for targeting its activity in several pathological conditions.
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spelling pubmed-79122992021-02-28 The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond Mosaoa, Rami Kasprzyk-Pawelec, Anna Fernandez, Harvey R. Avantaggiati, Maria Laura Biomolecules Review The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the impermeable mitochondrial membrane. Citrate is central to mitochondrial metabolism and respiration and plays fundamental activities in the cytosol, serving as a metabolic substrate, an allosteric enzymatic regulator and, as the source of Acetyl-Coenzyme A, also as an epigenetic modifier. In this review, we highlight the complexity of the mechanisms of action of this transporter, describing its involvement in human diseases and the therapeutic opportunities for targeting its activity in several pathological conditions. MDPI 2021-01-22 /pmc/articles/PMC7912299/ /pubmed/33499062 http://dx.doi.org/10.3390/biom11020141 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mosaoa, Rami
Kasprzyk-Pawelec, Anna
Fernandez, Harvey R.
Avantaggiati, Maria Laura
The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
title The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
title_full The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
title_fullStr The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
title_full_unstemmed The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
title_short The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
title_sort mitochondrial citrate carrier slc25a1/cic and the fundamental role of citrate in cancer, inflammation and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912299/
https://www.ncbi.nlm.nih.gov/pubmed/33499062
http://dx.doi.org/10.3390/biom11020141
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