Cargando…
The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912299/ https://www.ncbi.nlm.nih.gov/pubmed/33499062 http://dx.doi.org/10.3390/biom11020141 |
_version_ | 1783656545093943296 |
---|---|
author | Mosaoa, Rami Kasprzyk-Pawelec, Anna Fernandez, Harvey R. Avantaggiati, Maria Laura |
author_facet | Mosaoa, Rami Kasprzyk-Pawelec, Anna Fernandez, Harvey R. Avantaggiati, Maria Laura |
author_sort | Mosaoa, Rami |
collection | PubMed |
description | The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the impermeable mitochondrial membrane. Citrate is central to mitochondrial metabolism and respiration and plays fundamental activities in the cytosol, serving as a metabolic substrate, an allosteric enzymatic regulator and, as the source of Acetyl-Coenzyme A, also as an epigenetic modifier. In this review, we highlight the complexity of the mechanisms of action of this transporter, describing its involvement in human diseases and the therapeutic opportunities for targeting its activity in several pathological conditions. |
format | Online Article Text |
id | pubmed-7912299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79122992021-02-28 The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond Mosaoa, Rami Kasprzyk-Pawelec, Anna Fernandez, Harvey R. Avantaggiati, Maria Laura Biomolecules Review The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the impermeable mitochondrial membrane. Citrate is central to mitochondrial metabolism and respiration and plays fundamental activities in the cytosol, serving as a metabolic substrate, an allosteric enzymatic regulator and, as the source of Acetyl-Coenzyme A, also as an epigenetic modifier. In this review, we highlight the complexity of the mechanisms of action of this transporter, describing its involvement in human diseases and the therapeutic opportunities for targeting its activity in several pathological conditions. MDPI 2021-01-22 /pmc/articles/PMC7912299/ /pubmed/33499062 http://dx.doi.org/10.3390/biom11020141 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mosaoa, Rami Kasprzyk-Pawelec, Anna Fernandez, Harvey R. Avantaggiati, Maria Laura The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond |
title | The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond |
title_full | The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond |
title_fullStr | The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond |
title_full_unstemmed | The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond |
title_short | The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond |
title_sort | mitochondrial citrate carrier slc25a1/cic and the fundamental role of citrate in cancer, inflammation and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912299/ https://www.ncbi.nlm.nih.gov/pubmed/33499062 http://dx.doi.org/10.3390/biom11020141 |
work_keys_str_mv | AT mosaoarami themitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond AT kasprzykpawelecanna themitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond AT fernandezharveyr themitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond AT avantaggiatimarialaura themitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond AT mosaoarami mitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond AT kasprzykpawelecanna mitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond AT fernandezharveyr mitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond AT avantaggiatimarialaura mitochondrialcitratecarrierslc25a1cicandthefundamentalroleofcitrateincancerinflammationandbeyond |