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T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice

Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can rapidly progress to hemorrhaging and death. Case fat...

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Autores principales: Hawman, David W., Meade-White, Kimberly, Leventhal, Shanna, Carmody, Aaron, Haddock, Elaine, Hasenkrug, Kim, Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912317/
https://www.ncbi.nlm.nih.gov/pubmed/33572859
http://dx.doi.org/10.3390/microorganisms9020279
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author Hawman, David W.
Meade-White, Kimberly
Leventhal, Shanna
Carmody, Aaron
Haddock, Elaine
Hasenkrug, Kim
Feldmann, Heinz
author_facet Hawman, David W.
Meade-White, Kimberly
Leventhal, Shanna
Carmody, Aaron
Haddock, Elaine
Hasenkrug, Kim
Feldmann, Heinz
author_sort Hawman, David W.
collection PubMed
description Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can rapidly progress to hemorrhaging and death. Case fatality rates can be as high as 30%. An important gap in our understanding of CCHF are the host immune responses necessary to control the infection. A better understanding of these responses is needed to direct therapeutic strategies to limit the often-severe morbidity and mortality seen in humans. In this report, we have utilized a mouse model in which mice develop severe disease but ultimately recover. T-cells were robustly activated, differentiated to produce antiviral cytokines, and were critical for survival following CCHFV infection. We further identified a key role for interferon gamma (IFNγ) in survival following CCHFV infection. These results significantly improve our understanding of the host adaptive immune response to severe CCHFV infection.
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spelling pubmed-79123172021-02-28 T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice Hawman, David W. Meade-White, Kimberly Leventhal, Shanna Carmody, Aaron Haddock, Elaine Hasenkrug, Kim Feldmann, Heinz Microorganisms Article Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can rapidly progress to hemorrhaging and death. Case fatality rates can be as high as 30%. An important gap in our understanding of CCHF are the host immune responses necessary to control the infection. A better understanding of these responses is needed to direct therapeutic strategies to limit the often-severe morbidity and mortality seen in humans. In this report, we have utilized a mouse model in which mice develop severe disease but ultimately recover. T-cells were robustly activated, differentiated to produce antiviral cytokines, and were critical for survival following CCHFV infection. We further identified a key role for interferon gamma (IFNγ) in survival following CCHFV infection. These results significantly improve our understanding of the host adaptive immune response to severe CCHFV infection. MDPI 2021-01-29 /pmc/articles/PMC7912317/ /pubmed/33572859 http://dx.doi.org/10.3390/microorganisms9020279 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hawman, David W.
Meade-White, Kimberly
Leventhal, Shanna
Carmody, Aaron
Haddock, Elaine
Hasenkrug, Kim
Feldmann, Heinz
T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice
title T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice
title_full T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice
title_fullStr T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice
title_full_unstemmed T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice
title_short T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice
title_sort t-cells and interferon gamma are necessary for survival following crimean-congo hemorrhagic fever virus infection in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912317/
https://www.ncbi.nlm.nih.gov/pubmed/33572859
http://dx.doi.org/10.3390/microorganisms9020279
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