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Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model

Nutritional status during gestation can influence mother and offspring metabolism. Undernutrition in pregnancy affects women in both western and developing countries, and it is associated with a high prevalence of chronic diseases in later life. The present work was conducted in the rabbit model, as...

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Autores principales: García-García, Rosa M., Arias-Álvarez, María, Millán, Pilar, Rodríguez, María, Sánchez-Rodríguez, Ana, Lorenzo, Pedro L., Rebollar, Pilar G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912334/
https://www.ncbi.nlm.nih.gov/pubmed/33499108
http://dx.doi.org/10.3390/nu13020310
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author García-García, Rosa M.
Arias-Álvarez, María
Millán, Pilar
Rodríguez, María
Sánchez-Rodríguez, Ana
Lorenzo, Pedro L.
Rebollar, Pilar G.
author_facet García-García, Rosa M.
Arias-Álvarez, María
Millán, Pilar
Rodríguez, María
Sánchez-Rodríguez, Ana
Lorenzo, Pedro L.
Rebollar, Pilar G.
author_sort García-García, Rosa M.
collection PubMed
description Nutritional status during gestation can influence mother and offspring metabolism. Undernutrition in pregnancy affects women in both western and developing countries, and it is associated with a high prevalence of chronic diseases in later life. The present work was conducted in the rabbit model, as a longitudinal study, to examine the effect of food restriction during early and mid-gestation, and re-feeding ad libitum until the end of pregnancy on metabolic status and body reserves of mother and, its association with development and metabolism of fetuses and female offspring to the juvenile stage. Little changes in live body weight (LBW), compensatory feed intake, similar body reserves, and metabolism were observed in dams. Placenta biometry and efficiency were slightly affected, but fetal BW and phenotype were not modified. However, hyperinsulinemia, insulin resistance, and hypertriglyceridemia were demonstrated in pre-term fetuses. In the juvenile period, these changes were not evidenced, and a similar pattern of growth and serum metabolic parameters in offspring of food-restricted mothers were found, except in serum aminotransferases levels, which increased. These were associated with higher liver fibrosis. Maternal food restriction in the early and mid-pregnancy followed by re-feeding in our rabbit model established a compensatory energy status in dams and alleviated potential long-term consequences in growth and metabolism in the offspring, even if fetal metabolism was altered.
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spelling pubmed-79123342021-02-28 Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model García-García, Rosa M. Arias-Álvarez, María Millán, Pilar Rodríguez, María Sánchez-Rodríguez, Ana Lorenzo, Pedro L. Rebollar, Pilar G. Nutrients Article Nutritional status during gestation can influence mother and offspring metabolism. Undernutrition in pregnancy affects women in both western and developing countries, and it is associated with a high prevalence of chronic diseases in later life. The present work was conducted in the rabbit model, as a longitudinal study, to examine the effect of food restriction during early and mid-gestation, and re-feeding ad libitum until the end of pregnancy on metabolic status and body reserves of mother and, its association with development and metabolism of fetuses and female offspring to the juvenile stage. Little changes in live body weight (LBW), compensatory feed intake, similar body reserves, and metabolism were observed in dams. Placenta biometry and efficiency were slightly affected, but fetal BW and phenotype were not modified. However, hyperinsulinemia, insulin resistance, and hypertriglyceridemia were demonstrated in pre-term fetuses. In the juvenile period, these changes were not evidenced, and a similar pattern of growth and serum metabolic parameters in offspring of food-restricted mothers were found, except in serum aminotransferases levels, which increased. These were associated with higher liver fibrosis. Maternal food restriction in the early and mid-pregnancy followed by re-feeding in our rabbit model established a compensatory energy status in dams and alleviated potential long-term consequences in growth and metabolism in the offspring, even if fetal metabolism was altered. MDPI 2021-01-22 /pmc/articles/PMC7912334/ /pubmed/33499108 http://dx.doi.org/10.3390/nu13020310 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
García-García, Rosa M.
Arias-Álvarez, María
Millán, Pilar
Rodríguez, María
Sánchez-Rodríguez, Ana
Lorenzo, Pedro L.
Rebollar, Pilar G.
Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model
title Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model
title_full Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model
title_fullStr Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model
title_full_unstemmed Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model
title_short Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model
title_sort gestation food restriction and refeeding compensate maternal energy status and alleviate metabolic consequences in juvenile offspring in a rabbit model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912334/
https://www.ncbi.nlm.nih.gov/pubmed/33499108
http://dx.doi.org/10.3390/nu13020310
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