Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12

One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B–C (2,3) and three new α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by...

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Autores principales: Chen, Yan, Zou, Ge, Yang, Wencong, Zhao, Yingying, Tan, Qi, Chen, Lin, Wang, Jinmei, Ma, Changyang, Kang, Wenyi, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912375/
https://www.ncbi.nlm.nih.gov/pubmed/33498874
http://dx.doi.org/10.3390/md19020056
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author Chen, Yan
Zou, Ge
Yang, Wencong
Zhao, Yingying
Tan, Qi
Chen, Lin
Wang, Jinmei
Ma, Changyang
Kang, Wenyi
She, Zhigang
author_facet Chen, Yan
Zou, Ge
Yang, Wencong
Zhao, Yingying
Tan, Qi
Chen, Lin
Wang, Jinmei
Ma, Changyang
Kang, Wenyi
She, Zhigang
author_sort Chen, Yan
collection PubMed
description One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B–C (2,3) and three new α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC(50) values of 21.5 and 12.5 μM, respectively.
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spelling pubmed-79123752021-02-28 Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12 Chen, Yan Zou, Ge Yang, Wencong Zhao, Yingying Tan, Qi Chen, Lin Wang, Jinmei Ma, Changyang Kang, Wenyi She, Zhigang Mar Drugs Article One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B–C (2,3) and three new α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC(50) values of 21.5 and 12.5 μM, respectively. MDPI 2021-01-24 /pmc/articles/PMC7912375/ /pubmed/33498874 http://dx.doi.org/10.3390/md19020056 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yan
Zou, Ge
Yang, Wencong
Zhao, Yingying
Tan, Qi
Chen, Lin
Wang, Jinmei
Ma, Changyang
Kang, Wenyi
She, Zhigang
Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12
title Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12
title_full Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12
title_fullStr Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12
title_full_unstemmed Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12
title_short Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12
title_sort metabolites with anti-inflammatory activity from the mangrove endophytic fungus diaporthe sp. qym12
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912375/
https://www.ncbi.nlm.nih.gov/pubmed/33498874
http://dx.doi.org/10.3390/md19020056
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