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Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study

Background: The association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and prostate cancer (PC) remains unclear. Methods: We compared incident PC rates as a function of the Omega-3 Index [O3I, erythrocyte eicosapentaenoic and docosahexaenoic acids (EPA + DHA)] in 5607 men (40–...

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Autores principales: Farrell, Stephen W., DeFina, Laura F., Tintle, Nathan L., Leonard, David, Cooper, Kenneth H., Barlow, Carolyn E., Haskell, William L., Pavlovic, Andjelka, Harris, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912448/
https://www.ncbi.nlm.nih.gov/pubmed/33530576
http://dx.doi.org/10.3390/nu13020384
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author Farrell, Stephen W.
DeFina, Laura F.
Tintle, Nathan L.
Leonard, David
Cooper, Kenneth H.
Barlow, Carolyn E.
Haskell, William L.
Pavlovic, Andjelka
Harris, William S.
author_facet Farrell, Stephen W.
DeFina, Laura F.
Tintle, Nathan L.
Leonard, David
Cooper, Kenneth H.
Barlow, Carolyn E.
Haskell, William L.
Pavlovic, Andjelka
Harris, William S.
author_sort Farrell, Stephen W.
collection PubMed
description Background: The association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and prostate cancer (PC) remains unclear. Methods: We compared incident PC rates as a function of the Omega-3 Index [O3I, erythrocyte eicosapentaenoic and docosahexaenoic acids (EPA + DHA)] in 5607 men (40–80 years of age) seen at the Cooper Clinic who were free of PC at baseline. The average follow-up was 5.1 ± 2.8 years until censoring or reporting a new PC diagnosis. Proportional hazards regression was used to model the linear association between baseline O3I and the age-adjusted time to diagnosis. A meta-analysis of n-3 PUFA biomarker-based studies and incident PC was updated with the present findings. Results: A total of 116 cases of incident PC were identified. When O3I was examined as a continuous variable, the age-adjusted hazard ratio (HR) (95% CI) was 0.98 (0.89, 1.07; p = 0.25) for each 1% increment in the O3I. The updated meta-analysis with 10 biomarker-based studies found no significant relationship between EPA or DHA levels and risk for PC. Conclusions: We find no evidence in this study nor in a meta-analysis of similar studies that consuming n-3 PUFA-rich fish or using fish oil supplements affects the risk of PC.
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spelling pubmed-79124482021-02-28 Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study Farrell, Stephen W. DeFina, Laura F. Tintle, Nathan L. Leonard, David Cooper, Kenneth H. Barlow, Carolyn E. Haskell, William L. Pavlovic, Andjelka Harris, William S. Nutrients Article Background: The association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and prostate cancer (PC) remains unclear. Methods: We compared incident PC rates as a function of the Omega-3 Index [O3I, erythrocyte eicosapentaenoic and docosahexaenoic acids (EPA + DHA)] in 5607 men (40–80 years of age) seen at the Cooper Clinic who were free of PC at baseline. The average follow-up was 5.1 ± 2.8 years until censoring or reporting a new PC diagnosis. Proportional hazards regression was used to model the linear association between baseline O3I and the age-adjusted time to diagnosis. A meta-analysis of n-3 PUFA biomarker-based studies and incident PC was updated with the present findings. Results: A total of 116 cases of incident PC were identified. When O3I was examined as a continuous variable, the age-adjusted hazard ratio (HR) (95% CI) was 0.98 (0.89, 1.07; p = 0.25) for each 1% increment in the O3I. The updated meta-analysis with 10 biomarker-based studies found no significant relationship between EPA or DHA levels and risk for PC. Conclusions: We find no evidence in this study nor in a meta-analysis of similar studies that consuming n-3 PUFA-rich fish or using fish oil supplements affects the risk of PC. MDPI 2021-01-26 /pmc/articles/PMC7912448/ /pubmed/33530576 http://dx.doi.org/10.3390/nu13020384 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Farrell, Stephen W.
DeFina, Laura F.
Tintle, Nathan L.
Leonard, David
Cooper, Kenneth H.
Barlow, Carolyn E.
Haskell, William L.
Pavlovic, Andjelka
Harris, William S.
Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study
title Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study
title_full Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study
title_fullStr Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study
title_full_unstemmed Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study
title_short Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study
title_sort association of the omega-3 index with incident prostate cancer with updated meta-analysis: the cooper center longitudinal study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912448/
https://www.ncbi.nlm.nih.gov/pubmed/33530576
http://dx.doi.org/10.3390/nu13020384
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